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Cancer cells enlist adult stem cells to promote metastasis
10-31-2007 · Massachusetts Institute of Technology (MIT)MIT and Whitehead institute scientists have managed to facilitate metastasis, finding evidence that some breast cancer cells recruit normal adult stem cells from bone marrow and force them to secrete a protein that fosters cancer cell movement and invasion.
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Keywords: cancer, cells, enlist, adult, stem, promote, metastasis, cell, metastasi
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- Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
08-30-2007 · EurekAlert!
A drug that shuts down a critical cell-signaling pathway in the most common and aggressive type of adult brain cancer successfully kills cancer stem cells thought to fuel tumor growth and help cancers evade drug and radiation therapy, a Johns Hopkins study shows.
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- Researchers first to map gene that regulates adult stem cell growth
01-14-2007 · EurekAlert!
A new discovery in stem cell research may mean big things for cancer patients in the future. After being the first to genetically map and identify a gene that regulates adult stem cells, the researchers investigated the gene's protein product, Latexin, which can be used to ramp up the body's stem cell count. The team's findings are being published in Nature Genetics.
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- Cancer stem cell subpopulation drives metastasis of human pancreatic cancer
09-12-2007 · EurekAlert!
Scientists have identified a distinct subpopulation of cancer stem cells (CSCs) that is responsible for metastasis of a deadly human pancreatic cancer. The research, published by Cell Press in the Sept. issue of the journal Cell Stem Cell, provides insight into the role of CSCs in cancer initiation, progression and metastasis, and suggests new directions for development of more effective therapeutics.
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06-06-2007 · EurekAlert!
Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body's response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans.
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- Tumor-reactive T cells boosted by hematopoietic stem cell transplantation
02-01-2007 · EurekAlert!
Treatment for skin cancer by infusion of tumor-reactive T cells requires patients to be pre-treated with agents that transiently decrease the number of immune cells (nonmyeloablative agents). A study in mice now indicates that pre-treatment with more intense immune cell-depleting strategies (known as myeloablative strategies) and a hematopoietic stem cell transplant enables infused tumor-reactive CD8+ T cells to increase in number more than pre-treatment with nonmyeloablative agents, and this correlates with increased tumor regression.
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University of Michigan researchers have for the first time identified progenitor cells in mouse stomachs in a region where cancer often begins. The ability to see and trace these cells gives a green light to efforts to understand the origins of one of the world's most common cancers.
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- Cloned Mice Created From Fully Differentiated Cells, A Milestone In Cloning Research
10-02-2006 · ScienceDaily
New research dismisses the notion that adult stem cells are necessary for successful animal cloning, proving instead that cells that have completely evolved to a specific type not only can be used for cloning purposes, but they may be better and more efficient. As proof, researchers report they created two mouse pups from a type of blood cell that itself is incapable of dividing to produce a second generation of its own kind.
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02-12-2007 · EurekAlert!
Healthy and viable mice that survive until adulthood have, for the first time, been cloned from adult stem cells. The scientists used keratinocyte stem cells, which represent a new model system for cloning. Keratinocytes come from the skin, making them a particularly attractive stem cell source because of their ready accessibility. One day, they could be used to tailor therapies, as well as to better understand and treat diseases.
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How do adult stem cells protect themselves from accumulating genetic mutations that can lead to cancer?
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11-20-2007 · EurekAlert!
A simple recipe -- including just four ingredients -- can transform adult human skin cells into cells that resemble embryonic stem cells, researchers report in an immediate early publication of the journal Cell, a publication of Cell Press. The converted cells have many of the physical, growth and genetic features typically found in embryonic stem cells and can differentiate to produce other tissue types, including neurons and heart tissue, according to the researchers.
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