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Mice predict the effectiveness of orally taken drugs
11-01-2007 · EurekAlert!More than half of all orally-prescribed medications are broken down in the intestine and liver by an enzyme known as CYP3A before reaching their site of action. Researchers from the Netherlands Cancer Institute have now developed a mouse model for predicting the loss in available drug due to first-pass metabolism by CYP3A, providing a tool to help predict whether drugs being developed will work effectively if given orally.
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Keywords: mice, predict, effectiveness, orally, taken, drugs, drug
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