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How does the antitumor drug get to the cell nucleus?
11-02-2007 · EurekAlert!Platinum complexes such as the well-known cisplatin are powerful antitumor medications. But how does it get to the nucleus" Italian researchers have now proven that a copper transport protein may play a critical role.
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Keywords: antitumor, drug, cell, nucleus, nucleu
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- Support for chromosomal theory of cancer found in cancers' development of drug resistance
06-27-2007 · EurekAlert!
Most cancer researchers are convinced that cancer results from a handful of genetic mutations that kick a cell into uncontrolled growth. UC Berkeley genetics researcher Peter Duesberg disagrees, and finds support for his "chromosomal" theory of cancer in the development of drug resistance by many cancers. While his theory implies their is no magic bullet against cancer, it does provide ways to detect cancer at an early stage.
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- Using Life's Building Blocks to Control Nanoparticle Assembly
08-22-2007 · Brookhaven National Laboratory
Using DNA, researchers at Brookhaven are studying how to control both the speed of nanoparticle assembly and the structure of resulting nanoclusters. Learning how to control the assembly of nanoparticles could lead to applications from more efficient energy generation to cell-targeted systems for drug delivery.
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- Epilepsy-induced brain cell damage prevented in the laboratory
10-29-2007 · EurekAlert!
For some epilepsy patients, the condition's side effects can be as troubling as the seizures. One pressing concern is potential cognitive impairment from seizures, which can include memory loss, slowed reactions and reduced attention spans. Now researchers have linked such cognitive impairments to structural changes in brain cells caused by seizures. They report that the insights they gained allowed them to use a drug to block those changes in the brains of laboratory animals.
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- Building stronger bones, 1 stem cell at a time
01-24-2008 · EurekAlert!
Mesenchymal stem cells are capable of giving rise to various cell types through a process known as differentiation. A new study has determined that the anti-tumor drug bortezomib targets MSCs and leads to bone cell-specific differentiation. These data led the authors to suggest that Bzb might be a novel therapy for bone loss in individuals with osteoporosis and those with cancers accompanied by severe bone disease, such as myeloma.
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- UCLA researchers discover biomarkers that predict lung cancer patient response to therapy
01-31-2008 · EurekAlert!
Researchers at UCLA's Jonsson Cancer Center have discovered biomarkers that predict which patients with advanced non-small cell lung cancer will respond to a combination treatment of the anti-inflammatory drug Celebrex and the growth factor receptor blocker Tarceva.
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- Statin plus cancer drug deliver combo punch to brain cancer cells
01-18-2007 · EurekAlert!
Building on newly discovered genetic threads in the rich tapestry of biochemical signals that cause cancer, a Johns Hopkins Kimmel Cancer Center team has dramatically killed brain cancer cells by blocking those signals with a statin and an experimental antitumor drug.
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- Promising Antiobesity Drug Fails To Produce Clinically Meaningful Weight Loss
10-05-2006 · ScienceDaily
A drug designed to target a powerful hunger-stimulating factor that has long been considered a prime target for antiobesity therapy failed to produce clinically meaningful weight loss in obese people in a long-term clinical trial. People taking the drug known as MK-0557 for a year consistently lost about three pounds more than those taking a placebo, researchers reported in the October issue of the journal Cell Metabolism, published by Cell Press.
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- Sandia researchers discover way to see how a drug attaches to a cell
11-13-2006 · EurekAlert!
Sandia National Laboratories researchers John Shelnutt and Yujiang Song have discovered a better way to see where a drug attaches to a cell through a new process that produces novel hollow platinum nanostructures.
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- Cancer drug side effect caused by cell 'pump' problem
12-05-2006 · EurekAlert!
A troublesome side effect caused by some cancer drugs appears to be caused by a broken "pump" in the liver that fails to push these medicines into a "drain," according to investigators at St. Jude Children's Research Hospital.
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- JCI table of contents -- February 22, 2006
02-22-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, February 22, 2006, in the JCI, including: Drug blocks lethal motor-neuron disease in mice; Akt makes melanomas grow downward; PKC-epsilon links fat to insulin resistance; Neutrophils need glucose-6-phosphatase-beta; Unique cell population involved in granuloma formation in the intestine; and others.
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