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First-ever study: lack of critical lubricant causes wear in joints

For the first time, researchers have linked increased friction with early wear in the joints of animals. Work led by Brown University physician and engineer Gregory Jay, MD, shows mice that do not produce the protein lubricin begin to show wear in their joints less than two weeks after birth. This finding not only points up the protective power of lubricin but also suggests that it could be used to prevent joint wear after an injury.

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