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Cold Spring Harbor scientists devise novel, low-cost method of sifting genome's high-value regions
11-06-2007 · EurekAlert!Scientists at Cold Spring Harbor Laboratory have developed a new means of extracting and interpreting data from the human genome that is more powerful and more economical than methods currently employed. The new technology, called selective resequencing, promises to be a boon to many kinds of research, including efforts to comb vast stretches of the genome for mutant genes implicated in major diseases such as cancer and schizophrenia.
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- Harvard scientists partner to develop and distribute new tuberculosis vaccine
02-17-2007 · EurekAlert!
Bioengineers and public health researchers at Harvard University have developed a novel spraying method for delivering the most common tuberculosis (TB) vaccine, providing a new low-cost and scaleable technique that offers needle-free delivery and greater stability at room temperature than existing methods. The process could one day provide a better approach for vaccination against TB and help prevent the related spread of HIV/AIDS in the developing world.
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- Genomic 'firestorms' underlie aggressive breast cancer progression
11-30-2006 · EurekAlert!
The first high-resolution analysis of genomic alterations in breast tumors is reported in the scientific journal Genome Research. In this analysis, scientists from Cold Spring Harbor Laboratory, in collaboration with researchers from Scandinavia, identified three distinct patterns of genomic variation that underlie breast tumor formation, one of which -- "firestorms" -- may be predictive of aggressive disease progression and short survival.
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- Cost-effective method for gene silencing is featured in Cold Spring Harbor Protocols
08-01-2007 · EurekAlert!
The August, 2007 issue of Cold Spring Harbor Protocols includes a cost-effective approach for generating silencing RNAs, called esiRNAs, to efficiently target virtually any gene in mammalian cells.
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- Team of scientists develops non-invasive method to track nerve-cell development in live human brain
11-08-2007 · EurekAlert!
A team of scientists including researchers at Cold Spring Harbor Laboratory have identified and validated the first biomarker that permits neural stem and progenitor cells to be tracked, non-invasively, in the brains of living human subjects. This important advance could lead to significantly better diagnosis and monitoring of brain tumors and a range of serious neurological and psychiatric disorders.
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- Imaging techniques permit scientists to follow a day -- or four -- in the life of a cell
01-03-2007 · EurekAlert!
Understanding how live cells function is invaluable for molecular and cellular biologists, and advanced techniques to visualize cells in action are of great importance. The current issue of Cold Spring Harbor Protocols addresses this issue with two freely accessible protocols: one for inserting "reporter" proteins into cells to monitor what's going on inside, and another for maintaining the cells under a microscope for long-term observation.
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- CSHL scientists successfully target tumor microenvironment to stop cancer growth
06-15-2007 · EurekAlert!
Cold Spring Harbor Laboratory (CSHL) researchers led by Daniel Nolan and Assistant Professor Vivek Mittal have found that bone marrow (BM) derived endothelial progenitor cells (EPCs) play a critical role in the early stages of tumor progression and that eliminating EPCs stops cancer growth.
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- Shotgun sequencing finds nanoorganisms
12-21-2006 · EurekAlert!
UC Berkeley scientists Jill Banfield and Brett Baker have found some of the smallest organisms known in a sample of slime from a California mine. Their discovery proves the value of a technique called "shotgun" sequencing to identify all organisms in a microbial community, particularly those too small to see in a microscope, those very low in abundance, or those too novel to be picked up by PCR.
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- 454 Sequencing™ reveals new pathway in RNA interference
10-25-2006 · EurekAlert!
454 Life Sciences today announced that research on small RNAs, conducted by Cold Spring Harbor Laboratory, has revealed the dual role of the ARGONAUTE 4 protein (AGO4) in RNA-directed DNA methylation. The research, which describes a method for obtaining a comprehensive view of the total small RNAs from a single sample, was published today in Nature.
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- Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
10-14-2007 · EurekAlert!
Researchers at Baylor College of Medicine and Roche NimbleGen Inc. today have published details of a highly efficient and cost-effective method for capturing targeted regions of the genome via NimbleChip microarrays in preparation for high-throughput 454 Sequencing. The technology, called 'sequence capture,' enables fast and accurate enrichment of thousands of selected genomic regions, either contiguous or dispersed, such as segments of chromosomes or all genes or exons. The study appears online in the journal Nature Methods.
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- Cold Spring Harbor Protocols features innovative methods for embryology research
12-03-2007 · EurekAlert!
Two methods that permit scientists to examine critical stages in early embryogenesis are featured in this month's release of Cold Spring Harbor Protocols. The methods, which are freely accessible online, describe how to fluorescently tag cells in very young embryos.
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