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Speed is crucial in breaking protein's H-bonds
11-07-2007 · Massachusetts Institute of Technology (MIT)By slowing down the application of pressure in atomistic models, MIT researchers studying the architecture of proteins have explained why computer models of proteins' behavior under mechanical duress differ from experimental observations.
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Keywords: speed, crucial, breaking, protein, h-bonds, bonds
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- Speed plays crucial role in breaking protein's H-bonds
10-30-2007 · EurekAlert!
Researchers at MIT studying the architecture of proteins have finally explained why computer models of proteins' behavior under mechanical duress differ dramatically from experimental observations. This work could have vast implications in bioengineering and medical research by advancing our understanding of the relationship between structure and function in these basic building blocks of life.
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- Hemoglobin uncovered
11-06-2007 · EurekAlert!
Researchers at the BSC and the IRB Barcelona unveil crucial information about the protein transporter of oxygen, which opens up the possibility to optimize its function by introducing modifications. The study is published in the scientific journal Proceedings of the National Academy of Sciences.
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- Mutation may cause inherited neuropathy
12-25-2007 · EurekAlert!
Mutations in a protein called dynein, required for the proper functioning of sensory nerve cells, can cause defects in mice that may provide crucial clues leading to better treatments for a human nerve disorder known as peripheral neuropathy, which affects about three percent of all those over age 60.
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- Molecular motors may speed nutrient processing
05-30-2007 · EurekAlert!
Intestinal microvilli, finger-like protrusions on the cell surface, are packed with the motor protein myosin-1a. This myosin was thought to serve a purely structural role, but now Vanderbilt cell biologists Matthew Tyska and Russell McConnell have demonstrated that it is an active motor. They show that myosin-1a moves membrane toward the tips of intestinal microvilli, where the membrane buds off in vesicles. The findings have implications for nutrient processing and other aspects of gastrointestinal physiology.
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- Potential New Target For Leukemia Treatment
10-10-2006 · ScienceDaily
Cincinnati Children's Hospital Medical Center researchers have identified the crucial role and novel mechanism of action of the protein RhoH GTPase in the development and activation of cells critical to the immune system. The findings suggest that RhoH GTPase may provide a target for therapeutic intervention in some types of leukemia. The paper is due to appear in an upcoming edition of the journal, Nature Immunology.
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- Columbia scientists determine 3-dimensional structure of cell's 'fuel gauge'
02-08-2007 · EurekAlert!
Researchers at Columbia University Medical Center have uncovered the complex structure of a protein that serves as a central energy gauge for cells, providing crucial details about the molecule necessary for developing useful new therapies for diabetes and possibly obesity. A paper published online today in the journal Science details this structure, helping to explain one of the cell's most basic and critical processes.
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- Possible genetic link to schizophrenia identified
02-08-2007 · EurekAlert!
Several neurological and psychiatric disorders, including schizophrenia, are associated with changes in the brain that affect nerves that communicate with each other using dopamine. One protein that is crucial for dopamine-mediated neuronal communication in animals is DARPP-32. Now, researchers have shown that the gene that encodes DARPP-32 in humans exhibits genetic variation and that one particular variant is associated with increased performance in a number of cognitive tests and with an increased risk of schizophrenia.
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- Researchers discover gene crucial for nerve cell insulation
04-16-2007 · EurekAlert!
Researchers funded by the National Institutes of Health have discovered how a defect in a single master gene disrupts the process by which several genes interact to create myelin, a fatty coating that covers nerve cells and increases the speed and reliability of their electrical signals
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- Fire and structural safety a hot topic for engineers -- and the nation
06-05-2007 · EurekAlert!
Earthquakes and explosions grab the headlines when structures are toppled, but often the Achilles' heel of engineering is fire. Fire is the follow-up act in disasters. Yet in a research world awash in data keeping skyscrapers, bridges and buildings upright and safe in disaster, fire remains largely unstudied. A Michigan State professor says bringing the United States up to speed in integrating fire and structural engineering is crucial to homeland security.
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- Autism risk higher in people with gene variant
01-10-2008 · EurekAlert!
This study strengthens evidence that a gene, CNTNAP2, is involved in autism, and suggests that the link is strongest when a variation in the gene is inherited from moms, rather than dads. The gene encodes a protein that's known to mediate interactions between brain cells and that appears to enable a crucial aspect of brain-cell development. A gene variant that altered either of these activities could have significant impact.
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