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Mitochondria send death signal to cardiac cells, study shows
11-08-2007 · EurekAlert!Scientists have determined how cardiac cells die just as emergency treatments restore blood flow to a heart in distress, a paradox that has long puzzled doctors who are able to relieve pain in patients suffering from blocked arteries but can't stop the damage caused by the renewed rush of blood. The discovery may lead to new ways to save that dying tissue.
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Keywords: mitochondria, send, death, signal, cardiac, cells, study, shows, cell, show
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- International HIV/AIDS trial finds risks increase on episodic antiretroviral therapy
11-29-2006 · EurekAlert!
Results from one of the largest HIV/AIDS treatment trials ever conducted show that a specific strategy of interrupting antiretroviral therapy more than doubles the risk of AIDS or death from any cause. In the study, the investigators used two predetermined levels of CD4+ T cells, the primary immune cell targeted by HIV, to guide them in respectively suspending or restarting the study participants on antiretroviral therapy.
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- Calcium is spark of life, kiss of death for nerve cells
02-28-2007 · EurekAlert!
Oregon Health & Science University research shows how calcium regulates the recharging of high-frequency auditory nerve cells after they've fired a signal burst. The study indicates calcium ions play a greater role in keeping in check the brain's most powerful circuits, such as those used for processing sound signals, than previously thought. A better understanding of that role could someday help prevent the death of neurons behind such neurological disorders as stroke and multiple sclerosis.
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- Red cells count: Study shows pre-op levels affect post-op outcomes
06-12-2007 · EurekAlert!
Elderly men with even slightly abnormal red blood cell counts have a higher risk of dying or having a serious cardiac event after major surgery, according to a new study conducted by researchers at the Providence Veterans Affairs Medical Center and the Warren Alpert Medical School of Brown University. Results are published in JAMA.
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- A tricky tumor virus
01-17-2008 · EurekAlert!
Viruses use many tricks to gain control over their host cells and to reprogram them to their own advantage. Dr. Arnd Kieser and his colleagues of the Department of Gene Vectors of the Helmholtz Zentrum Munich, Germany, were able to show in a recent publication in PLoS Biology by which mechanism Epstein-Barr virus exploits a signal protein of its host cell, which normally mediates programmed cell death, in order to convert the cell into a cancer cell.
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- Therapeutic peptide frees the protein p73 to kill tumor cells
03-08-2007 · EurekAlert!
p53 suppresses tumor development by inducing tumor cell death. However, targeting p53 for the treatment of cancer is confounded by the fact that genetic mutations cause loss or inactivation of p53 in approximately 50 percent of human cancers. Now, a new study indicates that targeting the p53-related protein p73 in mice induces the regression of established tumors of human origin, leading to the suggestion that p73 might be a viable target for developing anticancer therapeutics.
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- Blood's clotting cells harbor 'ticking time bombs,' finding may help extend blood supply
03-22-2007 · EurekAlert!
Fragments of cells in the blood known as platelets—which form blood clots and assist in wound healing—have internal 'clocks' that act like ticking time bombs, predetermining their death from the moment they are born, according to a new study in the March 23 issue of the journal Cell, published by Cell Press.
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- Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells
02-05-2008 · EurekAlert!
Researchers are identifying innovative therapeutics for sickle cell anemia that focus on specific factors in the disease's progression, such as the important role of hydration of the red blood cells. According to a study prepublished online in Blood, the official journal of the American Society of Hematology, a novel small molecule therapy called senicapoc showed efficacy in maintaining hydration of red blood cells and increasing hemoglobin levels in patients with sickle cell anemia.
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- Study shows interruption of antiretroviral therapy increases risk of disease and death
11-30-2006 · EurekAlert!
Findings from one of the largest HIV/AIDS therapy studies show that a specific strategy of interrupting antiretroviral therapy more than doubles the risk of AIDS or death from any cause. Researchers affiliated with the Mailman School of Public Health led a large multi-center international study, known as Strategies for Management of Anti-Retroviral Therapies, or SMART, comparing two treatment strategies for people with human immunodeficiency virus. Findings demonstrate the value of continuous antiretroviral therapy.
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- Regulatory T cells require WASp if they are to prevent self-destruction
01-11-2007 · EurekAlert!
In humans, mutation of the gene encoding a protein known as WASp leads to susceptibility to infections and systemic autoimmunity. Most studies have focused on understanding how WASp deficiency causes defects in T cell activation, but a new study shows that in mice and humans a population of T cells known as regulatory T cells, which prevent other immune cells attacking the body's and causing autoimmunity, are also impaired in the absence of WASp.
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- Circulating fats kill transplanted pancreas cells, study shows
08-28-2007 · EurekAlert!
Dietary restrictions or other strategies that limit fat formation might make pancreatic cell transplants more effective, UT Southwestern Medical Center researchers report.
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