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Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
11-11-2007 · EurekAlert!An immune system messenger molecule that normally helps quiet inflammation could be an effective tool against multiple sclerosis. Neurology researchers at Jefferson Medical College have found that the protein interkeukin-27 (IL-27) helped block the onset or reverse symptoms in animals with an MS-like disease. The results suggest that IL-27 may someday be part of a therapy to temper over-active immune responses, which are thought to be at the heart of MS.
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12-12-2006 · EurekAlert!
A natural substance made from soy appears to have amazing restorative powers when given to animals with a multiple sclerosis (MS)-like disease. Using an animal model of MS, neurologists at Jefferson Medical College found that giving a substance called Bowmann-Birk Inhibitor Concentrate (BBIC) dramatically improved the animals' ability to move and walk. The scientists say the treatment’s effects may be useful in conjunction with more mainstream therapies such as beta-interferon in helping patients with MS.
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04-05-2007 · EurekAlert!
Immunology researchers at the Kimmel Cancer Center at Jefferson studying a multiple sclerosis (MS)-like disease in mice have shown that the amount of "damage" to the central nervous system’s protective blood-brain barrier -- in essence, opening it -- almost always correlates to the severity of the disease. The findings can be used for testing potential MS therapies and for better understanding the role of the blood-brain barrier in disease processes.
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- Targeting the adrenal gland could be key strategy against heart failure, Jefferson scientists show
02-18-2007 · EurekAlert!
Scientists have staved off heart failure in animals by using gene therapy to shut down the adrenal gland's excessive output of fight or flight hormones such as epinephrine and norepinephrine, which forces the heart to pump too hard. Such a novel approach -- targeting the adrenal gland in addition to the heart -- provides a potential new strategy against heart failure, and could lead to a new class of drugs.
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- Healthy bodies help fight disease? Clues to how diet affects the immune system
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- Molecule that destroys bone also protects it, new research shows
05-08-2007 · EurekAlert!
An immune system component that is a primary cause of bone destruction and inflammation in autoimmune diseases such as rheumatoid arthritis actually protects bone in the oral cavity from infectious pathogens that play a major role in periodontal disease in humans, research at the University at Buffalo has shown.
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- Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
06-01-2007 · EurekAlert!
A natural substance from fat cells can protect blood vessels from the damaging effects of inflammation, which contributes to heart disease. Researchers at Jefferson Medical College have shown for the first time in an animal model that the substance - a protein called adiponectin - helps prevent immune system white blood cells from binding to the inside of blood vessel walls. Harnessing adiponectin's properties may help protect against blood vessel damage in patients with obesity and diabetes.
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- Hot on the TRAIL of controlling inflammation in bacterial meningitis
06-14-2007 · EurekAlert!
In a study appearing online on June 14 in advance of publication in the July print issue of the Journal of Clinical Investigation, researchers at Charité-Universitätsmedizin Berlin report that the molecule known as TRAIL can limit excessive immune responses in bacterial meningitis, and as such may be of use to control inflammation of the spinal cord and brain, which causes brain cell death in this life-threatening disease.
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