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Researchers identify how to switch off cancer cell genes
11-12-2007 · EurekAlert!A new study led by researchers at the University of Southern California identifies how genes are silenced in cancer cells through distinct changes in the density of nucleosomes within the cells.
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Keywords: researchers, identify, switch, cancer, cell, genes, researcher, gene
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- 'Network' approach identifies potential breast cancer susceptibility gene
10-09-2007 · EurekAlert!
Like a crossword-puzzle solver who uses the letters in some answers to figure out others, researchers at Dana-Farber Cancer Institute and an international group of collaborators have used data on genes involved in inherited forms of breast cancer to identify a gene linked to non-hereditary cases of the disease.
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- Researchers first to map gene that regulates adult stem cell growth
01-14-2007 · EurekAlert!
A new discovery in stem cell research may mean big things for cancer patients in the future. After being the first to genetically map and identify a gene that regulates adult stem cells, the researchers investigated the gene's protein product, Latexin, which can be used to ramp up the body's stem cell count. The team's findings are being published in Nature Genetics.
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- Cold Spring Harbor Laboratory scientists discover new gene that prevents multiple types of cancer
02-09-2007 · EurekAlert!
A decades-old cancer mystery has been solved by researchers at Cold Spring Harbor Laboratory (CSHL). "We not only found a critical tumor suppressor gene, but have revealed a master switch for a tumor suppressive network that means more targeted and effective cancer therapy in the future," said CSHL Associate Professor Alea Mills, Ph.D. The study, headed by Mills, was published in the February issue of Cell.
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- Isolation of a new gene family essential for early development
08-22-2007 · EurekAlert!
Researchers at BRIC, University of Copenhagen, have identified new gene family essential for embryonic development. The family controls the expression of genes crucial for stem cell differentiation, and the results may contribute significantly to the understanding of cancer development. The results are published in Nature, and it follows up on two other high-impact articles on related gene families published in Nature and Cell by the same researchers within the last year.
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- Researchers identify unusual molecular switch for common form of advanced breast cancer
11-08-2007 · EurekAlert!
New evidence demonstrates that a novel molecular switch is involved in the development of a common form of advanced breast cancer, known as locally advanced breast cancer. The research, published by Cell Press in the Nov. 9, 2007 issue of Molecular Cell, provides an exciting paradigm shift in the understanding of a key event in breast cancer development and presents new therapeutic opportunities for this deadly disease.
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- St. Jude researchers identify key genetic trigger of acute myeloid leukemia
11-26-2007 · EurekAlert!
A gene called N-Myc leads a double life in certain white blood cells, helping to trigger a cancer called acute myeloid leukemia (AML) under some conditions while triggering apoptosis, or cell suicide, under other conditions, according to results of a mouse study done by investigators at St. Jude Children's Research Hospital.
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- Firefly genes allow testing of new therapy against lymphoma
12-19-2007 · EurekAlert!
Researchers here have figured out a way to use a firefly gene to let them see just how effective a new drug combination actually is against some forms of cancer and its serious complication. The new study looked at ATLL, adult T cell lymphoma and leukemia, a form of cancer where it is particularly hard to gauge the disease's progress, and where the patients' prognosis is generally poor. There is now no widely effective therapy available to treat this disease successfully.
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- Novel regulation of the common tumor suppressor PTEN
01-11-2007 · EurekAlert!
PTEN is one of the most commonly mutated tumor suppressor genes. It is an antagonist for many cellular growth, proliferation and survival processes. When mutated or deleted, it causes cancers of the prostate, breast, colon and brain. Researchers led by scientists at Memorial Sloan-Kettering Cancer Center have now identified fundamentally novel regulatory mechanisms of PTEN function. The findings from two related studies are published in the Jan. 12 issue of Cell.
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- Scientists map key landmarks in human genome
01-16-2007 · EurekAlert!
Dana-Farber Cancer Institute researchers have developed a powerful method for charting the positions of key gene-regulating molecules called nucleosomes throughout the human genome. The mapping tool could help uncover important clues for understanding and diagnosing cancer and other diseases, the scientists say. Moreover, it may shed light on the role of nucleosomes in the process of "reprogramming" an adult cell to its original embryonic state, which is a critical operation in cloning.
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- Computer tool helps pinpoint risky gene mutations
02-15-2007 · EurekAlert!
Certain cancer risks can be passed down through families, the result of tiny changes in a family's genetic code. But not all genetic changes are deadly. To help medical counselors and physicians identify the mutations that pose the greatest health risks, researchers have developed and validated a new computer tool.
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