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Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration

Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease. In research with mice, scientists now have discovered more specific information about how this inherited expansion of a normal repeated DNA sequence alters gene expression.

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Keywords: abnormal, glutamine, repeats, interfere, key, transcription, factor, leading, neurodegeneration, repeat

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