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Telomerase enzyme structure provides significant new target for anti-cancer therapies
11-13-2007 · EurekAlert!Inappropriate activation of a single enzyme, telomerase, is associated with the uncontrollable proliferation of cells seen in as many as 90 percent of all of human cancers. Scientists have long eyed the enzyme as an ideal target for developing broadly effective anti-cancer drugs. Now, researchers working at the Wistar Institute have brought this goal closer by deciphering the 3-D structure of a domain, or region, of the telomerase molecule essential for the enzyme's activity.
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- Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
08-13-2007 · EurekAlert!
Two new studies may lead to the development of more effective therapies for individuals with multiple myeloma, a common and incurable blood cell cancer. The research, published by Cell Press in the August issue of the journal Cancer Cell, provides new insight into the molecular mechanisms that underlie aberrant NF-κB activity in MM tumor cells and underscores the relevance of the signaling pathway as a target for MM therapy.
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- Epigenetic drugs, promising for breast cancer treatment
12-20-2006 · EurekAlert!
Worldwide, cancer persists as one of the most important diseases that affect the human being. The knowledge on the molecular bases of cancer generated during the last decades has been successfully translated into small but significant gains in overall cancer survival rates due to better primary prevention measures, improved diagnostic methods and the development of more effective and specific therapies, collectively termed "molecular targeted therapies." In the context of these new forms of treatment, epigenetic or transcriptional cancer therapy is clearly promising.
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- A new target for the treatment of breast cancer
01-11-2007 · EurekAlert!
The active ingredient in a drug currently being tested to treat rheumatoid arthritis might also one day serve as an effective means of treating one of the deadliest forms of breast cancer. Berkeley Lab researchers have demonstrated that inhibiting the activity of the protease enzyme known as TACE can deprive tumor cells of a key factor needed for their proliferation. TACE is strongly present in a form of breast cancer which responds poorly to current therapies.
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- T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
09-18-2007 · EurekAlert!
Human white blood cells, engineered to recognize other malignant immune cells, could provide a novel therapy for patients with highly lethal B cell cancers such as acute lymphoblastic leukemia, according to researchers at Memorial Sloan-Kettering Cancer Center. By administering repeated doses of T cells designed to express an artificial receptor which recognizes human B cells, the researchers were able to eradicate cancer in 44 percent of mice bearing human ALL tumors.
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- OHSU lab finds meth receptor that could lead to therapy
04-18-2007 · EurekAlert!
A recently discovered signaling system in the brain has just been shown to be turned on by methamphetamine, an Oregon Health & Science University study found. The signaling system could soon become a target for therapies aiming to reverse meth's adverse health effects as well as reduce the craving that drives its abuse. "… We provide clear evidence that methamphetamine is a full and potent agonist of TAAR1," says OHSU researcher Dr. David Grandy.
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- Estrogen study provides new impetus for development of colon cancer drugs
12-18-2006 · EurekAlert!
Estrogen may hold important clues for scientists working on new therapies for colon cancer, a study by Dana-Farber Cancer Institute researchers suggests. The investigators found that postmenopausal women with colon cancer lived longer and had less likelihood of dying of the disease if they had been taking estrogen supplements within five years of their diagnosis. The researchers stress that these findings do not mean estrogen should be viewed as a treatment or preventive therapy.
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- Enzyme structure reveals new drug targets for cancer and other diseases
02-14-2008 · EurekAlert!
Researchers now have a clearer understanding of how a key protein controls gene activity and how mutations in the protein may cause disease. The work could provide new avenues to design drugs aimed at cancer, diabetes, HIV, and heart disease.
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- Integrated approach to radiation therapy provides quality care for cancer patients
11-07-2006 · EurekAlert!
Results from a University of Pittsburgh study demonstrate that intensity-modulated radiation therapy (IMRT) can be uniformly delivered in a large health care system of academic and community cancer centers through a centralized planning and treatment process. According to study results, there were no significant differences in toxicity profiles and recommended radiation dose prescriptions in 758 prostate cancer patients treated with IMRT at 12 separate community cancer centers and one academic flagship facility.
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- Integrated approach to IMRT provides quality care for head and neck cancer patients
10-28-2007 · EurekAlert!
Results from a University of Pittsburgh study demonstrate that intensity-modulated radiation therapy can be uniformly delivered in a large healthcare system of academic and community cancer centers through a centralized planning and treatment process. According to study results, there were no significant differences in toxicity profiles and recommended radiation dose prescriptions in 604 head and neck cancer patients treated with IMRT at 12 separate community cancer centers and one academic flagship facility.
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- Brown researchers make major signal transduction discovery
10-04-2007 · EurekAlert!
How cells sense and respond to chemical messages -- a process known as signal transduction -- is a fundamental force in biology, controlling key processes such as cell growth and immune response. Now researchers from the Warren Alpert Medical School of Brown University and Rhode Island Hospital report a significant discovery in the field of signal transduction that could provide a new target for drugs that fight cancer, HIV and diseases. Results are published in Cell.
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