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Tailored treatments: Promising designer drug provides new insight into cancer biology
11-13-2006 · EurekAlert!Scientists are making progress toward unraveling the molecular mysteries that underlie cancer progression and treatment resistance. Two studies in the November 2006 issue of the journal Cancer Cell, published by Cell Press, provide mechanistic details that may explain why the small-molecule chemical ABT-737 is emerging as a unique and effective anticancer agent.
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- Queen's discovery provides new hope for people with advanced breast cancer
01-15-2007 · EurekAlert!
A surprising discovery by Queen's University researchers that happened when their work took an unexpected turn may help women with advanced breast cancer respond better to conventional drug treatments.
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- Study pries into ovarian cancer's deadly secrets
04-11-2007 · EurekAlert!
A new study sheds light on cell defects that lead to one common type of ovarian cancer and puts forth a promising new mouse model that already is being used for preclinical drug testing. The study focuses on ovarian endometrioid adenocarcinoma, the second most common form of a baffling, deadly disease for which early detection methods and effective treatments have been elusive so far.
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- New insight into factors that drive muscle-building stem cells
01-08-2008 · EurekAlert!
A report in the January issue of Cell Metabolism, a publication of Cell Press, provides new evidence explaining how stem cells known as satellite cells contribute to building muscles up in response to exercise. These findings could lead to treatments for reversing or improving the muscle loss that occurs in diseases such as cancer and AIDS as well as in the normal aging process
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- New clinical trial results show how personalized medicine will alter treatment of genetic disorders
12-26-2007 · EurekAlert!
In the latest edition of the New England Journal of Medicine, Eric Hoffman, PhD, posits that the results of a clinical trial involving a new treatment for Duchenne muscular dystrophy provides a proof-of-principle for personalized molecular medicine. He writes that advances allowing for systemic delivery of such drugs and provide proof of no long term toxicity for recipients are necessary but will likely come in short order. Moving forward, FDA regulations will prove critical for appropriate labeling and marketing of such personalized treatments.
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- Fantastic Voyage: A New Nanoscale View Of The Biological World
10-06-2006 · ScienceDaily
Echoing the journey through the human body in "Fantastic Voyage," doctors might soon be able to track individual donor cells after a transplant, or to find where and how much of a cancer treatment drug there is within a cell. New technology described in a study published in the open access journal, Journal of Biology makes it possible to image and quantify molecules within individual mammalian or bacterial cells.
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- Cancer drug works by overactivating cancer gene
11-20-2007 · EurekAlert!
University of Michigan researchers have discovered that bortezomib, a promising cancer drug, is able to strike a blow against melanoma tumor cells by revving up the action of a cancer-promoting gene. The results suggest a novel treatment strategy: push cancer cells into overdrive, so that they self-destruct. The laboratory-based findings may lead to ways to give bortezomib with reduced side effects.
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- Scientists gain important insights into acute promyelocytic leukemia
07-09-2007 · EurekAlert!
Results from two new studies provide key mechanistic insights into the complex molecular events that cause a deadly type of leukemia. The research, published in the July issue of the journal Cancer Cell, published by Cell Press, illuminates specific mechanisms involved in development of acute promyelocytic leukemia and identifies promising new avenues to develop treatments for some of its variant forms.
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- Scientists follow familiar TRAIL to new cancer therapy
07-09-2007 · EurekAlert!
A new study identifies a combination therapy that may sensitize human cancer cells to a promising treatment currently being used in clinical trials. The research, published in the July issue of the journal Cancer Cell, published by Cell Press, provides a pharmacological method for enhancing the potency and effectiveness of a tumor necrosis factor death receptor ligand against a variety of human cancers.
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- Scientists, physicians present latest findings in 'personalized' cancer treatment and prevention
09-10-2007 · EurekAlert!
Scientists and clinicians from around the world will gather in Atlanta, Ga., next week at the American Association for Cancer Research's second International Conference on Molecular Diagnostics in Cancer Therapeutic Development. The conference is subtitled "Maximizing Opportunities for Personalized Treatment," which reflects the potential of molecular diagnostics to provide new strategies for tailoring therapies to fit the needs of each cancer patient's unique biology.
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- Tailoring glioblastoma therapies: 1 size does not fit all
02-06-2008 · EurekAlert!
An upcoming G&D paper from Dr. Azad Bonni and colleagues at HarvardMedical School lends new insight into how the unique genetic signature of glioblastoma tumors affects treatment efficacy -- a finding with promising hope for the therapeutic targeting of the leading cause of cancer-related deaths in the young and middle-aged population.
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