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ClC-1 helps mice get a move on

One symptom of myotonic dystrophy is the inability to voluntarily relax the muscles. DM originates from complex genetic mutations that result in abnormalities of several muscle proteins, including ClC-1. A new study, has established that abnormal inclusion of a specific region of the ClC-1 gene in ClC-1 mRNA has a role in the development of disease in mouse models of DM and developed an approach to correct this, eliminating myotonia.

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Keywords: clc-1, mice, move, clc

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