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Flawed Stem Cells Yield Fragile X Clues: Researchers study genetic disorder via discarded embryos

11-17-2007 · Science News Online

The most common inherited cause of mental retardation arises when a mutated gene is shut down early in embryonic development.

Keywords: flawed, stem, cells, yield, fragile, clues, researchers, study, genetic, disorder, via, discarded, embryos, cell, clue, researcher, embryo

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Loss of stem cells correlates with premature aging in animal study
06-06-2007 · EurekAlert!
Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body's response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans.
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Researchers discover important tool in understanding differentiation in human embryonic stem cells
10-24-2007 · EurekAlert!
Researchers at the University of Minnesota's Stem Cell Institute have used an existing genetic tool to study how human embryonic stem cells self-renew. The researchers used "knockdown" technology to reduce the expression, and plasmid vectors to increase the expression of oct4, a gene known to be necessary for self renewal. Both procedures resulted in differentiation, but with similar patterns, unlike mouse ES cells that differentiate into a different cell types with oct4 up-and down-regulation.
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Human embryonic stem cells derived from preimplantation genetically diagnosed embryos
11-14-2007 · EurekAlert!
A human stem cell line derived from embryos that were identified by preimplantation genetic diagnosis to carry the mutation for fragile X syndrome has provided an unprecedented view of early events associated with this disease. In addition to giving scientists fresh insight into fragile X, results from this unique model system have emphasized the value of this new source of embryonic stem cells and may have a significant impact on the way that genetic diseases are studied in the future.
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Stem cell research produces a key discovery for Fragile X Syndrome
09-10-2007 · EurekAlert!
An important finding has been made by McMaster researchers about Fragile X Syndrome, a sex-linked genetic disorder that affects approximately one in 4,000 males and one in 6,000 females.
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Researchers reveal repressor protein blocks neural stem cell development
10-10-2007 · EurekAlert!
A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Medical Institute researchers published online Oct. 10 in Nature.
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St. Jude researchers identify key genetic trigger of acute myeloid leukemia
11-26-2007 · EurekAlert!
A gene called N-Myc leads a double life in certain white blood cells, helping to trigger a cancer called acute myeloid leukemia (AML) under some conditions while triggering apoptosis, or cell suicide, under other conditions, according to results of a mouse study done by investigators at St. Jude Children's Research Hospital.
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UF researchers test stem cell therapy for heart patients
10-04-2007 · EurekAlert!
University of Florida doctors treated the first patient in a new study to test whether a person's own stem cells can be used to restore blood flow to the heart by prompting new blood vessels to grow.
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Study reveals how stem cells decide to become either skeletal or smooth muscle
10-10-2007 · EurekAlert!
Researchers have discovered that a key protein controls how stem cells 'choose' to become either skeletal muscle cells that move limbs, or smooth muscle cells that support blood vessels. The results suggest new ways to treat atherosclerosis and cancer, diseases that involve the creation of new blood vessels from stem cell reserves that would otherwise replace worn out skeletal muscle.
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Human stem cells delay start of Lou Gehrig's disease in rats
10-15-2006 · EurekAlert!
Researchers at Johns Hopkins have shown that transplanting human stem cells into spinal cords of rats bred to duplicate Lou Gehrig's disease delays the start of nerve cell damage typical of the disease and slightly prolongs life. The grafted stem cells develop into nerve cells that make substantial connections with existing nerves and do not themselves succumb to Lou Gehrig's, also known as amyotrophic lateral sclerosis (ALS). The study is published in this week's issue of Transplantation.
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USC study in Nature Genetics supports a stem cell origin of cancer
01-08-2007 · EurekAlert!
Researchers at the University of Southern California found genes that are reversibly repressed in embryonic stem cells are over-represented among genes that are permanently silenced in cancers.
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