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Synthetic compound promotes death of lung-cancer cells, tumors
11-12-2007 · UT Southwestern Medical CenterHuman lung-cancer tumors grown in mice have been shown to regress or disappear when treated with a synthetic compound that mimics the action of a naturally occurring “death-promoting” protein found in cells, researchers at UT Southwestern Medical Center report.
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Keywords: synthetic, compound, promotes, death, lung-cancer, cells, tumors, promote, lung, cancer, cell, tumor
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- Synthetic compound promotes death of lung-cancer cells, tumors
11-12-2007 · EurekAlert!
Human lung cancer tumors grown in mice have been shown to regress or disappear when treated with a synthetic compound that mimics the action of a naturally occurring 'death-promoting' protein found in cells, researchers at UT Southwestern Medical Center report.
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- Therapeutic peptide frees the protein p73 to kill tumor cells
03-08-2007 · EurekAlert!
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- A genetic 'gang of 4' drives spread of breast cancer
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Studies of human tumor cells implanted in mice have shown that the abnormal activation of four genes drives the spread of breast cancer to the lungs. The new studies by Howard Hughes Medical Institute researchers reveal that the aberrant genes work together to promote the growth of primary breast tumors. Cooperation among the four genes also enables cancerous cells to escape into the bloodstream and penetrate through blood vessels into lung tissues.
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- 2 microRNAs promote spread of tumor cells
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Scientists at The Wistar Institute and their colleagues have identified two microRNAs that promote tumors' deadly spread. One of the miRNAs may provide an early warning of metastatic breast cancer and the need for aggressive treatment. In a study to be published Feb. 1 in Nature Cell Biology that is available online, the researchers describe how two miRNAs transformed non-invasive human breast cancer cells into cells that rapidly metastasized in cell cultures and mice.
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- FOXO factor promotes survival of oxygen-deprived cancer cells
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- CSHL scientists identify cells that promote formation of lethal lung metastases
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Cancer patients usually ask what can be done after a primary tumor has already spread, or metastasized, to other organs. In many cases, they learn, little can be done. Hence the importance of a discovery by scientists at Cold Spring Harbor Laboratory of a type of cell that regulates the transformation of small, dormant lung metastases into large, aggressive metastases -- the kind that kill cancer patients.
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Chemical compounds specially designed to neutralize proteins that would otherwise allow tumor cells to cheat death have been recognized for some time by scientists as a promising new avenue for cancer therapy. Now, two studies in the Nov. 16, 2007 issue of the journal Cell, a publication of Cell Press, provide insight into just how these antagonists of the anti-death -- so-called Inhibitor-of-Apoptosis (IAP) -- proteins work to fight tumors.
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- Penn researchers identify new combination therapy that promotes cancer cell death
07-16-2007 · EurekAlert!
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Lung cancer cells with a defective version of a potential tumor suppressor gene are highly resistant to attack by a platinum-based drug commonly used to treat the disease, researchers at the University of Texas M. D. Anderson Cancer Center and the University of Texas Southwestern Medical Center at Dallas report in the cover article of the Oct. 1 edition of Cancer Research.
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