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New technique captures chemical reactions in a single living cell at unprecedented resolution
11-19-2007 · EurekAlert!A team of UC Berkeley bioengineers have developed a technique that for the first time enables the detection of chemical signals from biomolecules in a single living cell with unprecedented resolution. By coupling metallic nanoparticles with biomolecules, researchers can obtain information critical to cell-based drug discovery, early disease detection and biomedical diagnostics.
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Keywords: technique, captures, chemical, reactions, single, living, cell, unprecedented, resolution, capture, reaction
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- Lasers Shine Light on Chemical Reactions
11-22-2006 · Brookhaven National Laboratory
Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have been using a high-resolution laser technique to learn how molecules absorb light and fall apart during photodissociation reactions - chemical decomposition reactions triggered by light. Studying the atomic-level details of such reactions allows scientists to test and refine theories of chemical reactions, and may help them in their quest to use light to control reaction outcomes.
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- Biocapture surfaces produced for study of brain chemistry
12-13-2007 · EurekAlert!
A novel method has been developed for attaching small molecules, such as neurotransmitters, to surfaces, which then are used to capture large biomolecules. Researchers can make the technique applicable to a wide range of "bait" molecules including drugs, chemical warfare agents, and environmental pollutants. Ultimately, the researchers also hope to identify synthetic biomolecules that recognize neurotransmitters so that they can fabricate extremely small biosensors to study neurotransmission in the living brain.
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- With Record Resolution And Sensitivity, Tool Images How Life Organizes In A Cell Membrane
10-02-2006 · ScienceDaily
What's the difference between a lifeless sack of chemicals and a living cell? It's all in the way they're organized, according to Stanford biophysical chemist Steven Boxer. With colleagues at Stanford, the University of California-Davis and Lawrence Livermore National Laboratory, he has developed a way to image cell membranes with unprecedented resolution-on the order of 100 nanometers, a scale larger than individual molecules but much smaller than entire cells.
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- Scientists see DNA get 'sunburned' for the first time
02-01-2007 · EurekAlert!
For the first time, scientists have observed DNA being damaged by ultraviolet (UV) light. Chemists used a special technique to watch strands of DNA in the laboratory sustain damage in real time. They observed the most common chemical reaction among a family of reactions on the DNA molecule that are linked to sunburn, and discovered that this key reaction happens with astounding speed.
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- A Moment in the Life of a Cell: Microscopic scan images without intruding
08-18-2007 · Science News Online
A laser technique similar to a CAT scan produces 3-D images of living cells without the need for chemical staining.
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- New MIT technique weighs single living cells
04-25-2007 · Massachusetts Institute of Technology (MIT)
For the first time, MIT researchers have found a way to measure the mass of single cells with high accuracy. The technique could allow researchers to develop inexpensive diagnostic devices and offer a unique glimpse into cell division.
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- To catch an intermediate
12-21-2006 · EurekAlert!
A new technique for capturing the short-lived but critical "intermediate" compounds that help carry chemical reactions which take place in aqueous solution from their starting point to the final product has been developed by researchers with the US Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab). This technique basically entails temporarily trapping the elusive transients inside molecular pyramids.
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- MIT creates 3-D images of living cell
08-12-2007 · EurekAlert!
A new imaging technique developed at MIT has allowed scientists to create the first 3-D images of a living cell, using a method similar to the X-ray CT scans doctors use to see inside the body.
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- DNA gets new twist: Carnegie Mellon scientists develop unique 'DNA nanotags'
01-26-2007 · EurekAlert!
Carnegie Mellon University scientists have married bright fluorescent dye molecules with DNA nanostructure templates to make nanosized fluorescent labels that hold considerable promise for studying fundamental chemical and biochemical reactions in single molecules or cells. The work, published online Jan. 26 in the Journal of the American Chemical Society, improves the sensitivity for fluorescence-based imaging and medical diagnostics.
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- DNA sieve -- Nanoscale pores can be tiny analysis labs
05-11-2007 · EurekAlert!
A international team led by researchers at the National Institute of Standards and Technology has proven for the first time that a single nanometer-scale pore in a thin membrane -- resembling one found in a living cell -- can be used to accurately detect and sort different-sized polymer chains (a model for biological molecules) that pass through the channel.
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