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Giving asthma T(he)SL(i)P by blocking OX40

Inflammatory disorders such as asthma and eczema are overzealous immune responses by the body to otherwise innocuous environmental conditions. The protein TSLP is a potent activator of the allergic inflammatory response, and a new report has identified a role for another protein, OX40, in TSLP-induced allergic reactions in mice and monkeys. These data point to the interaction between OX40 and its partner protein, OX40L, as a promising therapeutic target for the treatment of allergic diseases.

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Keywords: giving, asthma, blocking, ox40

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