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Protein protects brain against compound in lead poisoning, liver disease
12-06-2007 · EurekAlert!Scientists have discovered that a protein known as PEPT2 protects the brains of mice from a naturally occurring but potentially toxic compound present in lead poisoning and in a class of liver diseases that can cause serious neurological complications.
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Keywords: protein, protects, brain, compound, lead, poisoning, liver, disease, protect
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- Carbon monoxide protects mice from multiple sclerosis
01-25-2007 · EurekAlert!
Multiple sclerosis (MS) is a chronic inflammatory disorder that causes degeneration of the nerves in the brain and spinal cord, leading to various symptoms including muscle weakness and pain. Using a mouse model of MS (known as EAE), researchers have now shown that increased expression of a protein known as HO-1, as well as administration of carbon monoxide, protects mice from disease.
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- Green tea extract protects against brain damage in new mouse model of HIV-related dementia
05-01-2007 · EurekAlert!
A green tea extract may represent a new and natural compound for preventing and treating HIV-associated dementia, a study using a new mouse model for the devastating disease suggests.
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- Animal study identifies potential treatment for Huntington's disease
10-08-2007 · EurekAlert!
Mass. General Institute for Neurodegererative Disorders researchers have identified a compound that may lead to a treatment that could protect against the effects of Huntington's Disease. Their report describes how a small molecule called C2-8 appears to delay the loss of motor control and reduce neurological damage in a mouse model of the disorder.
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- Blocking immune cell action increases Alzheimer's-associated protein deposits
03-27-2007 · EurekAlert!
The immune system's response against amyloid-beta, the protein that forms plaques in the brains of patients with Alzheimer's disease, appears to protect the brain from damage in early stages of the devastating neurological disorder. A report from Massachusetts General Hospital researchers finds that lack of a protein required for recruitment of the brain's primary immune cell led to increased amyloid-beta deposits and earlier death in a mouse model of Alzheimer's disease.
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- Why bad things can happen to the heart when 'good' cholesterol goes bad
08-22-2007 · EurekAlert!
It's yet another example of how a good thing can go bad: Researchers have found evidence in laboratory studies that "good" cholesterol, renowned for its ability to protect against heart disease, can undergo detrimental changes in protein composition that make it "bad" for the heart. The study could lead to new lab tests and treatments for heart disease, they say. It will be presented in August at the American Chemical Society national meeting in Boston.
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- Early environmental exposure may accelerate age-related neurodegeneration
06-27-2007 · EurekAlert!
Exposure to iron during the first weeks of life in combination with exposure later in life to a common herbicide may contribute to the subsequent degeneration of brain cells associated with the onset of Parkinson's disease (PD), according to a new study in mice. The findings also showed that a compound that protects cells in the body from damage from certain forms of oxygen, a kind of antioxidant, could suppress such neural degeneration.
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- Study confirms imaging compound identifies amyloid-beta in human brain
03-12-2007 · EurekAlert!
A team led by Massachusetts General Hospital investigators has confirmed that the imaging agent Pittsburgh Compound B (PiB) binds to the protein in amyloid plaques that characterize Alzheimer's disease in the human brain. Their report describes the first postmortem neuropathological study of a dementia patient who had previously participated in a PET imaging study using PiB.
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- Breaking down Huntington's disease one protein at a time
02-04-2008 · EurekAlert!
Hoping to piece together the intricate series of interactions that lead to Huntington's disease, Indiana University Bloomington scientists have determined the shape and structure of a binding site that may prove useful in combating the neurodegenerative disease.
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- Brain Seasoning: A common spice could deter Alzheimer's
07-21-2007 · Science News Online
A compound in the curry spice turmeric restores the ability of immune system cells to destroy plaques linked to Alzheimer's disease.
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- Copper damages protein that defends against Alzheimer's
11-06-2007 · EurekAlert!
Copper can damage a molecule that escorts out of the brain a substance called amyloid beta that builds up in toxic quantities in the brains of people with Alzheimer's disease. The new findings demonstrate one way in which copper might contribute to the development of the disease, though scientists say much more research needs to be done to clarify what role, if any, copper ultimately plays.
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