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Gene is associated with aggressive prostate cancer

12-11-2007 · EurekAlert!

A variant of a tumor suppressor gene may be associated with an increased risk of aggressive prostate cancer, according to a study published online Dec. 11 in the Journal of the National Cancer Institute.

Keywords: gene, associated, aggressive, prostate, cancer

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Study finds gene linked to aggressive prostate cancer
12-11-2007 · EurekAlert!
Results from two genome-wide association studies have identified a genetic variant of the DAB2IP gene that is associated with the risk of aggressive prostate cancer. Research teams from the Translational Genomics Research Institute, Wake Forest University School of Medicine, the Karolinska Institute in Stockholm, Sweden, and Johns Hopkins Medical Institutions made the discovery jointly.
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Other highlights in the Aug. 28 JNCI
08-28-2007 · EurekAlert!
Also in the Aug. 28 JNCI are H. pylori strains that are associated with precancerous gastric lesions, a gene that blocks the spread of prostate cancer, and a study on the risk of neutropenia in patients taking irinotecan.
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Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
10-11-2007 · EurekAlert!
A tumor-blocking protein previously implicated in prostate and breast cancer development may also be behind the most aggressive type of pancreatic cancer. Researchers have discovered that the protein pp32 -- which normally applies the brakes on a cancer-causing gene -- is missing in an aggressive form of pancreatic cancer. Though the work is preliminary, the scientists say, the absent protein could eventually become a marker for the disease and a potential drug target.
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Cancer-resistant mouse discovered
11-27-2007 · EurekAlert!
A mouse resistant to cancer, even highly-aggressive types, has been created by researchers at the University of Kentucky. The breakthrough stems from a discovery by UK College of Medicine professor of radiation medicine Vivek Rangnekar and a team of researchers who found a tumor-suppressor gene called "Par-4" in the prostate.
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Scientists discover genetic variant associated with prostate cancer in African Americans
10-31-2007 · EurekAlert!
Researchers report a new genetic variant that is linked to higher incidence of prostate cancer in African-American men. This study emphasizes the importance of characterizing genetic markers associated with prostate cancer in high-risk populations.
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Evolutionary battle scars' identify enhanced antiviral activity
01-24-2008 · EurekAlert!
Rapid evolution of a protein produced by an immunity gene is associated with increased antiviral activity in humans, a finding that suggests evolutionary biology and virology together can accelerate the discovery of viral-defense mechanisms, according to researchers at Fred Hutchinson Cancer Research Center in Seattle. These findings, published Jan. 25 in the open-access journal PLoS Genetics, present a striking example by which evolutionary studies can directly lead to biomedically important discoveries in the field of infectious diseases.
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Faulty gene linked to prostate cancer risk
10-30-2006 · EurekAlert!
Missing sections of a gene, which programs the manufacture of a chemical to alert the body to DNA damage, almost doubles the risk of prostate cancer, reveals research published ahead of print in the Journal of Medical Genetics.
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Other highlights in the September 11 JNCI
09-11-2007 · EurekAlert!
Also in the September 11 JNCI, a study on how multiple prostate biopsies effect cancer diagnosis, an immune system gene that may be linked to lung cancer survival, and a cancer-killing virus that targets stem cells.
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Higher physical activity associated with reduced risk of breast cancer
12-11-2006 · EurekAlert!
Women with higher levels of physical activity may have a reduced risk of breast cancer after menopause, according to a report in the December 11/25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. The association appears to be stronger for estrogen receptor positive/progesterone receptor negative tumors (which are typically more aggressive) than for other types of breast cancer tumors.
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No magic tomato? Study breaks link between lycopene and prostate cancer prevention
05-17-2007 · EurekAlert!
Tomatoes might be nutritious and tasty, but don't count on them to prevent prostate cancer. In the May issue of Cancer Epidemiology, Biomarkers & Prevention, researchers based at the National Cancer Institute and Fred Hutchinson Cancer Research Center report that lycopene, an antioxidant predominately found in tomatoes, does not effectively prevent prostate cancer. In fact, the researchers noted an association between beta-carotene, an antioxidant related to lycopene, and an increased risk for aggressive prostate cancer.
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