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Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease
12-13-2007 · EurekAlert!Researchers discover a new regulatory element in a region of the cystic fibrosis gene that can control the gene's expression in the gastrointestinal tract, offering new insight into it's role in the development of digestive diseases.
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Keywords: study, uncovers, clues, cystic, fibrosis, gene, dysfunction, gastrointestinal, disease, uncover, clue, fibrosi
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10-18-2007 · EurekAlert!
Cystic fibrosis is an inherited disease caused by mutations in the CFTR gene. Each mutation has number of effects on lung cells. New in vitro evidence published in the Journal of Clinical Investigation has provided insight into the mechanisms by which one of these changes impacts both CF and the complications of CF, providing support for ongoing clinical trials and raising the possibility of new targets for the development of drugs to treat CF.
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- Clues to gene expression in cystic fibrosis will guide research
03-28-2007 · EurekAlert!
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- Secondhand smoke exposure worsens cystic fibrosis
01-29-2008 · EurekAlert!
Researchers at Johns Hopkins have discovered the first genetic evidence that secondhand smoke can worsen lung disease. The report in this week's Journal of the American Medical Association describes one gene variation that can weaken lung function as well as shorten the lifespan of those affected by cystic fibrosis and also are exposed to secondhand smoke.
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09-04-2007 · EurekAlert!
The results of a clinical trial, published in late August in the Journal of Pediatrics, indicates that, when used as part of routine therapy, high-dose ibuprofen is safe and effective in slowing down lung disease in children with cystic fibrosis (CF).
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Exposure to secondhand smoke is associated with adverse effects on lung function among persons with cystic fibrosis, with this effect being worse for persons with certain gene variations, according to a study in the Jan. 30 issue of JAMA.
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11-03-2006 · EurekAlert!
Researchers have found a highly unusual distribution of proteins in the lungs and airways of people with cystic fibrosis. The discovery is preliminary, but intriguing: Finding out more about the proteins could help sort out the immune system's role in the disease. The study will be presented at a meeting of the American Physiological Society, "Physiological Genomics and Proteomics of Lung Disease," on Nov. 3.
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- UCLA study uncovers clues for why Graves' disease attacks the eyes
03-01-2007 · EurekAlert!
UCLA researchers have uncovered new clues that may explain why Graves' disease attacks the muscle tissue behind the eyes, often causing them to bulge painfully from their sockets. The findings may deepen understanding of how the autoimmune disorder damages the body and offer a new target for treating the disfiguring disease.
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02-05-2008 · EurekAlert!
An unexpected finding turned out to be a clue leading researchers at Washington University School of Medicine in St. Louis to propose a new treatment approach for Niemann-Pick disease, a rare, deadly neurodegenerative disorder. They believe the approach also could be useful for more common diseases -- such as cystic fibrosis -- that stem from a similar type of defect.
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11-30-2006 · EurekAlert!
A recent University of Iowa study reveals a new immune defense mechanism in normal airways and may help explain why people with cystic fibrosis are particularly susceptible to bacterial lung infections. The findings also may point the way to new approaches for treating the disease.
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- Dragonfly's metabolic disease provides clues about human obesity
11-20-2006 · EurekAlert!
Parasite-infected dragonflies suffer the same metabolic disorders that have led to an epidemic of obesity and type 2 diabetes in humans, according to research to be published in the Proceedings of the National Academy of Science. The discovery expands the known taxonomic breadth of metabolic disease and suggests that the study of microbes found in human intestines may provide a greater understanding of the root causes of human metabolic dysfunction.
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