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Herceptin helps women with multiple chromosomes containing HER2 gene, study finds
12-14-2007 · EurekAlert!The targeted therapy Herceptin helps women with HER2+ type of breast cancer independent of whether patients have extra copies of chromosome 17, home to the HER2 gene which produces the HER2 protein that fuels cancer growth. Prior to this report, there were conflicting opinions about whether that was the case, say Mayo Clinic investigators who presented their findings at the San Antonio Breast Cancer Symposium.
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Keywords: herceptin, women, multiple, chromosomes, containing, her2, gene, study, chromosome
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- New protein implicated in autism
03-22-2007 · EurekAlert!
Autism is a common neurodevelopmental disorder characterized by severely impaired social, communicative, and behavioral functions. Although several genes are associated with autism, none lie in the region of human chromosome 7 associated with autism susceptibility. Now, a new study demonstrates that mice lacking CADPS2, which is encoded by a gene in the autism susceptibility region of human chromosome 7, exhibit autistic-like characteristics, leading to the suggestion that CADPS2 defects might predispose individuals to autism.
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- High blood pressure medication strategy proves effective in Hispanic women
07-12-2007 · EurekAlert!
Researchers studied 22,500 patients enrolled in the landmark International Verapamil SR-Trandolapril study, known as INVEST, and tracked a subgroup of 5,017 Hispanic and 4,710 non-Hispanic white women who were randomly assigned to a drug strategy containing either a sustained release form of the calcium antagonist verapamil or the beta-blocker atenolol. Hispanic women achieved greater blood pressure control and were half as likely as white women to suffer adverse outcomes.
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- Delay in use of nevirapine-based AIDS treatment can improve outcomes
01-10-2007 · EurekAlert!
Delaying the use of nevirapine-containing antiretroviral therapy (ART) for at least six months after labor may improve treatment outcomes among HIV-infected women in developing countries who took nevirapine during labor to prevent their babies from becoming infected, suggests a new study in the New England Journal of Medicine. The study, led by a researcher at Harvard School of Public Health and Brigham and Women's Hospital, appears in the January 11, 2007, issue of the journal.
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- International study points to new breast cancer-susceptibility gene
02-08-2007 · EurekAlert!
A gene whose existence was detected only a couple of years ago may increase women's risk of breast cancer when inherited in a mutated form, and may contribute to prostate cancer as well, researchers at Dana-Farber Cancer Institute and colleagues in Finland report in a new study.
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- Gene patenting -- steep cost for health care and patients
05-07-2007 · EurekAlert!
The drug trastuzumab (Herceptin) is used to treat HER2-positive breast cancer (a type of breast cancer that overexpresses the HER2 gene and accounts for about 25 percent of all breast cancers). Trastuzumab therapy improves the chances of survival; however, it has deleterious side effects and is expensive. Thus, it is important to accurately determine the patient's HER2 status.
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- Family structure size could affect breast cancer risk prediction accuracy for BRCA gene testing
06-19-2007 · EurekAlert!
Researchers have found that the probability of the breast cancer gene mutation BRCA among women with a history of breast cancer is greater when the number of older, female relatives in the family is smaller, according to a study in the June 20 issue of JAMA. This finding may challenge the accuracy of some breast cancer prediction models, which may not take family structure into account.
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- Study identifies multiple genetic risk factors for prostate cancer
04-01-2007 · EurekAlert!
A study led by researchers at the Keck School of Medicine of the University of Southern California and Harvard Medical School has identified seven genetic risk factors that predict risk for prostate cancer. According to the study's findings, these risk factors are clustered in a single region of the human genome on chromosome 8 and powerfully predict a man's probability of developing prostate cancer.
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- Multiple corticosteroid injections in pregnant women may increase cerebral palsy
09-21-2007 · EurekAlert!
In pregnant women at high risk for preterm birth, a single injection of corticosteroids has been shown to reduce the baby's chances of having serious lung problems after birth. A new study shows that repeat courses of corticosteroids are linked to an increased rate of cerebral palsy among children of these mothers.
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- Lupus in women: New genetic risk factors identified
01-20-2008 · EurekAlert!
An international consortium of clinical scientists and genomics experts, including researchers from the Montreal Heart Institute and Université de Montréal, have uncovered multiple new genetic risk factors for systemic lupus erythematosus, commonly known as lupus. The large-scale genomic study is the first of its kind to investigate the genetic basis of lupus.
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- Novel MS drug shows promise in 2 lethal leukemias
08-28-2007 · EurekAlert!
A new study suggests that an experimental drug being tested for the treatment of multiple sclerosis and to prevent organ rejection might also help people with certain deadly forms of chronic and acute leukemia. The laboratory and animal study focused on the drug, called fingolimod. Researchers said it might help patients with advanced chronic myelogenous leukemia or acute lymphocytic leukemia, and whose cancer cells show a particular genetic change called the Philadelphia chromosome.
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