Daily non-political popular news in brief.
Novel regulatory mechanism identified for key tumor suppressor p53
11-15-2006 · EurekAlert!Collaborating scientists from the Wistar Institute in Philadelphia and the Vienna Biocenter in Austria have identified a novel mechanism involved in normal repression of the p53 protein, perhaps the single most important molecule for the control of cancer in humans. The new molecular pathway described in the study suggests intriguing approaches to diagnosing or intervening in the progression of many types of cancer.
Read more »
Keywords: novel, regulatory, mechanism, identified, key, tumor, suppressor, p53
« Previous | Next »
Similar news on "Novel regulatory mechanism identified for key tumor suppressor p53":
- Novel regulation of the common tumor suppressor PTEN
01-11-2007 · EurekAlert!
PTEN is one of the most commonly mutated tumor suppressor genes. It is an antagonist for many cellular growth, proliferation and survival processes. When mutated or deleted, it causes cancers of the prostate, breast, colon and brain. Researchers led by scientists at Memorial Sloan-Kettering Cancer Center have now identified fundamentally novel regulatory mechanisms of PTEN function. The findings from two related studies are published in the Jan. 12 issue of Cell.
Similar news · Read more »
- Scripps research scientists identify new regulatory mechanism for critical protein signaling domain
04-05-2007 · EurekAlert!
In a study with far-reaching implications, scientists at the Scripps Research Institute and other institutions have for the first time identified a new in vivo regulatory mechanism for the PH Domain, a component of many proteins that allows them to move from a cell's interior to the cell membrane in response to stimulation of cell surface receptors. The findings offer a promising avenue for the development of novel therapies for immunodeficiency or autoimmune diseases.
Similar news · Read more »
- Penn researchers find diabetes drug kills some cancer cells
08-14-2007 · EurekAlert!
Researchers have found that a commonly prescribed diabetes drug kills tumor cells that lack a key regulatory gene called p53. Results from current studies in mice may result in new therapies for a subset of human cancers that tend to be aggressive and resistant to existing treatments.
Similar news · Read more »
- DMP1 deletion cooperates with oncogenic K-ras in lung cancer
10-15-2007 · EurekAlert!
Scientists have identified the transcription factor DMP1 as a pivotal tumor suppressor for both human and mouse lung cancers, especially in carcinomas that exhibit intact Arf-p53 pathways. The research, published by Cell Press in the October 2007 issue of Cancer Cell, may lead to development of new drug therapies for lung cancer.
Similar news · Read more »
- Bits of 'junk' RNA aid master tumor-suppressor gene
08-23-2007 · EurekAlert!
A University of Michigan study reveals that the p53 gene, a key protector mutated in half of all cancers, gets help in its vital job of stifling tumors from a trio of little-known micro RNA genes. Drugs that mimic their benefits could become important tools in cancer therapy someday.
Similar news · Read more »
- Master regulatory gene of epithelial stem cells identified
05-03-2007 · EurekAlert!
The skin's ability to replace the tissue it sloughs off is controlled by a variety of genes. A new study from Harvard Medical School published in the May 4 issue of Cell, however, identifies a "master regulator" of this regeneration process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be the p63 gene, a close relative to the well-known tumor-suppressing p53 gene.
Similar news · Read more »
- Important mechanism identified in the formation of blood vessels
01-29-2007 · EurekAlert!
All tissues, sick and healthy alike, need a blood supply to survive and grow. The key to many medical problems, like preventing tumor development, is therefore to obstruct the spread of the blood vessels. Research scientists at Karolinska Institutet have now discovered a heretofore unknown mechanism for how the body links together its blood vessels.
Similar news · Read more »
- Pioneering study looks at p53’s Role in tumor-stroma interactions
10-25-2006 · EurekAlert!
Researchers have conducted the first comprehensive study of the role an important tumor suppressor gene plays in cancer development. P53 is known as a major tumor suppressor that is frequently mutated in human cancer. In this study, researchers used novel proteomic techniques to identify the proteins secreted by cells specifically in response to p53. The findings suggest a newfound role for wt-p53 in the control of the tumor's ability to communicate with the normal stromal cells surrounding it.
Similar news · Read more »
- Muscle weakness: New mutation identified
06-14-2007 · EurekAlert!
New research, published in the Journal of Physiology, has identified a novel mutation associated with muscle weakness and distal limb deformities. The study demonstrates that muscle weakness experienced by persons with a regulatory protein tropomyosin mutation is directly related to a mechanism by which the mutant tropomyosin modulates contractile speed and force-generation capacity.
Similar news · Read more »
- Pioneering study looks at p53's role in tumor-stroma interactions
10-25-2006 · EurekAlert!
Researchers have conducted the first comprehensive study of the role an important tumor suppressor gene plays in cancer development. P53 is known as a major tumor suppressor that is frequently mutated in human cancer. In this study, researchers used novel proteomic techniques to identify the proteins secreted by cells specifically in response to p53. The findings suggest a newfound role for wt-p53 in the control of the tumor's ability to communicate with the normal stromal cells surrounding it.
Similar news · Read more »
