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CSHL scientists identify and repress breast cancer stem cells in mouse tissue
12-17-2007 · EurekAlert!By manipulating highly specific gene-regulating molecules called microRNAs, scientists at Cold Spring Harbor Laboratory report that they have succeeded in singling out and repressing stem-like cells in mouse breast tissue -- cells that are widely thought to give rise to cancer.
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Keywords: cshl, scientists, identify, repress, breast, cancer, stem, cells, mouse, tissue, scientist, cell
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06-11-2007 · EurekAlert!
At the heart of most, if not all cancers, lie a handful of wayward stem cells that feed the ever growing tumor mass, but their scarcity make it difficult for scientists to study them. Now, times of plenty may lie ahead as a breast cancer cell line -- established long ago -- turned out to behave a lot like cancer stem cells.
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- Cancer cells enlist adult stem cells to promote metastasis
10-31-2007 · Massachusetts Institute of Technology (MIT)
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- Newly created cancer stem cells could aid breast cancer research
08-13-2007 · EurekAlert!
Scientists have created breast cancer stem cells in culture by isolating and transforming a particular population of cells from normal human breast tissue. After being injected with just 100 of these transformed cells, mice develop tumors that metastasize. When scientists performed the same transformation process on a slightly different population of cells from the identical human breast tissue, the resulting cancer cells were 10,000 times less potent as tumor initiators and could not move to other tissues.
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- Scientists identify a mouse embryonic stem cell more like our own
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Scientists have discovered a new type of mouse embryonic stem cell that is the closest counterpart yet to human embryonic stem cells, the National Institutes of Health announced today. The cells are expected to serve as an improved model for human ES cells in studies of regeneration, disease pathology and basic stem cell biology.
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Cancer patients usually ask what can be done after a primary tumor has already spread, or metastasized, to other organs. In many cases, they learn, little can be done. Hence the importance of a discovery by scientists at Cold Spring Harbor Laboratory of a type of cell that regulates the transformation of small, dormant lung metastases into large, aggressive metastases -- the kind that kill cancer patients.
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Scientist can now identify pluripotent stem cells based solely on their physical appearance.
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A Dana-Farber Cancer Institute study challenges the hypothesis that "cancer stem cells" -- a small number of self-renewing cells within a tumor -- are responsible for breast cancer progression and recurrence, and that wiping out these cells alone could cure the disease.
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- Algae Provide New Clues To Cancer
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A microscopic green alga helped scientists at the Salk Institute for Biological Studies identify a novel function for the retinoblastoma protein (RB), which is known for its role as a tumor suppressor in mammalian cells. By coupling cell size with cell division, RB ensures that cells stay within an optimal size range.
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Working with embryonic mouse brains, a team of Johns Hopkins scientists seems to have discovered an almost-too-easy way to distinguish between "true" neural stem cells and similar, but less potent versions. Their finding could simplify the isolation of stem cells not only from brain but also other body tissues.
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