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RNA interference therapy heals growth deficiency disorder in a live animal
12-18-2007 · EurekAlert!A team of Vanderbilt researchers have demonstrated for the first time that a new type of gene therapy, called RNA interference, can heal a genetic disorder in a live animal.
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Keywords: rna, interference, therapy, heals, growth, deficiency, disorder, live, animal, heal
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- CSHL researchers show RNA splicing factor may be new target for cancer therapy
02-18-2007 · EurekAlert!
New results in the field of RNA research establish that the RNA splicing factor SF2/ASF can act as a cancer-causing protein by changing the alternative splicing of other genes critical for growth-control of cells.
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- Colon cancer a disease of hormone deficiency, Jefferson team finds
08-01-2007 · EurekAlert!
Researchers have found new evidence suggesting that colon cancer is a disease of missing hormones that could potentially be treated by hormone replacement therapy.Early in colon cancer development, two intestinal cell growth-controlling hormones are "lost," disrupting the activity of the hormones' receptor, GCC. Using two mouse models of colon cancer development in people, the scientists showed that GCC signaling blocks tumors from forming, meaning that colon cancer could be a disease of hormone insufficiency.
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- No proof that growth hormone therapy makes you live longer, Stanford study finds
01-15-2007 · EurekAlert!
Surveyors of anti-aging elixirs tout human growth hormone as a remedy for all things sagging-from skin to libidos -- and claim it can even prevent or reverse aging. But researchers at the Stanford University School of Medicine say there's no evidence to suggest that this purported fountain of youth has any more effect than a trickle of tap water when it comes to fending off Father Time.
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- Signal protein shows promise for blocking tumor promoters in skin cells
11-03-2006 · EurekAlert!
A protein with the ironic name "Srcasm" can counteract the effects of tumor-promoting molecules in skin cells. Using animal models, the researchers discovered that Srcasm acts like a brake in epithelial cells, preventing uncontrolled cell growth caused by a family of proteins called Src kinases. This finding, published online in the Journal of Biological Chemistry, suggests a target for future gene therapy to treat skin, head, neck, colon and breast cancers.
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- The RNA drug revolution -- a new approach to gene therapy
01-23-2008 · EurekAlert!
RNA interference represents an innovative new strategy for using small RNA molecules to silence specific genes associated with disease processes, and a series of review articles describing the state-of-the-art and potential therapeutic applications of RNAi and microRNAs will begin with two review papers in the January 2008 issue (Volume 19, No. 1) of Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc. The papers are available free online.
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- Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model
06-02-2007 · EurekAlert!
Rats with erectile dysfunction that were injected with a gene therapy vector containing either of two nerve growth factors were able to regain normal function after four weeks, according to a study conducted by University Pittsburgh School of Medicine researchers. These findings are being presented at the 10th annual meeting of the American Society of Gene Therapy, which is convening May 30 to June 3 at the Washington State Convention & Trade Center, Seattle.
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- RNAi shows promise in gene therapy, Stanford researcher says
02-18-2007 · EurekAlert!
Three years ago Mark Kay, MD, PhD, published the first results showing that a biological phenomenon called RNA interference could be an effective gene therapy technique. Since then he has used RNAi gene therapy to effectively shut down the viruses that cause hepatitis and HIV in mice.
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- JCI table of contents: May 1, 2007
05-01-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, May 1, 2007, in the JCI, including: "OCT1 required for therapeutic effects of diabetes drug Metformin"; "One genetic mutation heals another in blistering skin disease"; "Why wounds are slow to heal in diabetics"; "Researchers create 2 distinct mouse models of Omenn syndrome"; and "Deficiency in enzyme GGTase-I delays onset and severity of lung cancer in mice."
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- Fragile X retardation syndrome corrected in mice
12-19-2007 · EurekAlert!
Researchers working with mice have significantly alleviated a wide range of abnormalities due to fragile X syndrome by altering only a single gene, countering the effects of the fragile X mutation. They said their achievement offers the potential for treatment of the disorder, the most common form of inherited mental retardation and a leading identified genetic cause of autism. There is currently no treatment or therapy for fragile X syndrome, whose symptoms include mental retardation, epilepsy and abnormal body growth.
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- Scripps research combination therapy obliterates new vessel growth in tumors and retinopathy
01-09-2007 · EurekAlert!
Using a new and dramatically effective treatment approach, scientists at the Scripps Research Institute have for the first time achieved complete inhibition of new blood vessel growth in animal models of a highly vascular brain tumor and of neovascular eye diseases with little or no effect on normal tissue vasculature.
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