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iNOS expression may links chronic biliary inflammation to malignant transformation

A study by Dr. Kitasato and colleagues demonstrated that cytokine stimulation induced iNOS expression and NO generation, which was sufficient to cause DNA damage in normal hamster gallbladder epithelial cells. These findings suggest that NO-mediated oxidative DNA damage produced by inflammatory cytokines through iNOS expression is involved in an initiation process that links chronic biliary inflammation to malignant transformation.

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Keywords: inos, expression, links, chronic, biliary, inflammation, malignant, transformation, ino, link

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