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St. Jude finds link between cellular defense processes, showing how cancer cells survive
12-19-2007 · EurekAlert!St. Jude Children's Research Hospital investigators have discovered that immune system cells that engulf and destroy germs in the body enlist help for this task from a common housekeeping mechanism that most cells use to keep their interiors healthy.
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Keywords: jude, link, cellular, defense, processes, showing, cancer, cells, survive, processe, cell
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- Novel regulation of the common tumor suppressor PTEN
01-11-2007 · EurekAlert!
PTEN is one of the most commonly mutated tumor suppressor genes. It is an antagonist for many cellular growth, proliferation and survival processes. When mutated or deleted, it causes cancers of the prostate, breast, colon and brain. Researchers led by scientists at Memorial Sloan-Kettering Cancer Center have now identified fundamentally novel regulatory mechanisms of PTEN function. The findings from two related studies are published in the Jan. 12 issue of Cell.
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- St. Jude researchers identify key genetic trigger of acute myeloid leukemia
11-26-2007 · EurekAlert!
A gene called N-Myc leads a double life in certain white blood cells, helping to trigger a cancer called acute myeloid leukemia (AML) under some conditions while triggering apoptosis, or cell suicide, under other conditions, according to results of a mouse study done by investigators at St. Jude Children's Research Hospital.
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- Scientists identify switch for brain's natural anti-oxidant defense
10-19-2006 · EurekAlert!
Scientists at Dana-Farber Cancer Institute report they have found how the brain turns on a system designed to protect its nerve cells from toxic "free radicals," a waste product of cell metabolism that has been implicated in some degenerative brain diseases, heart attacks, strokes, cancer and aging.
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- Tumor cells evade death through autophagy
01-18-2007 · EurekAlert!
Autophagy (a process that enables cells to turnover their contents) is initiated in tumor cells by chemotherapy and radiation, but it is not known if this causes tumor cell death or helps tumor cells survive. A new mouse study now indicates that autophagy is a survival mechanism for tumor cells treated with agents that initiate tumor cell death, suggesting that adjunct treatment with autophagy inhibitors might increase the efficacy of some chemotherapeutics in cancer patients.
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- Innovative movies show real-time immune-cell activity within tumors
11-20-2006 · EurekAlert!
Using advanced new microscopy techniques in concert with sophisticated transgenic technologies, scientists have for the first time created three-dimensional, time-lapse movies showing immune cells targeting cancer cells in live tumor tissues. Immune cells called T cells can be seen actively migrating though tissues, making direct contact with tumor cells, and killing them. Insights from this new view of the body's on-board defenses against cancer may open the way for improved immunotherapies to treat the disease.
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- Loss of cell's 'antenna' linked to cancer's development
06-28-2007 · EurekAlert!
Most normal vertebrate cells have cilia, small hair-like structures that protrude like antennae into the surrounding environment to detect signals that control cell growth. In a new study published in the June 29 issue of Cell, Fox Chase Cancer Center researchers describe the strong link between ciliary signaling and cancer, and identify the rogue engineers responsible for dismantling the cell's antenna.
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- Preventing cancer without killing cells
03-30-2007 · EurekAlert!
Inducing senescence in aged cells may be sufficient to guard against spontaneous cancer development, according to a paper published online this week in EMBO reports. It was previously unknown whether cellular senescence or programmed cell death -- apoptosis -- was the more important safeguard mechanism for suppressing tumours arising from dysfunctional telomeres.
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- FOXO factor promotes survival of oxygen-deprived cancer cells
12-27-2007 · EurekAlert!
Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on the growth of tumors, depending on whether or not the tumor cells have enough oxygen. The research, published by Cell Press in the Dec. 28 issue of Molecular Cell, provides critical new information about how normal cells and cancer cells survive under stress.
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- Neural stem cell study reveals mechanism that may play role in cancer
09-04-2007 · EurekAlert!
In the dynamic world of the developing brain, neural stem cells give rise to neurons deep within the brain’s fluid-filled ventricles. These newborn neurons then migrate along the stem cell fibers up to the neocortex, the seat of higher cognitive functions. Now, scientists have discovered a key mechanism of this migration -- one that may also play an important role in other developmental processes and diseases, including cancer.
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- Fetal cell 'transplant' could be a hidden link between childbirth and reduced risk of breast cancer
10-02-2007 · EurekAlert!
Some benefits of motherhood are intangible, but one has been validated through biostatistical research: women who bear children have a reduced risk of developing breast cancer. In Seattle, researchers at the University of Washington and Fred Hutchinson Cancer Research Center believe they have identified a source of this protective effect: fetal cells "transplanted" to the mother before birth.
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