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Breast cancer risk varies among women who are carriers of BRCA1 and BRCA2 gene mutations

Breast cancer risk varies widely among women who are carriers of the BRCA1 and BRCA2 mutations, according to a new study published in the Jan. 9, 2008, issue of the Journal of the American Medical Association.

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Keywords: breast, cancer, risk, varies, women, carriers, brca1, brca2, gene, mutations, vary, carrier, mutation

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1. Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene
   01-01-2008 · EurekAlert!
   Israeli investigators have found that Ashkenazi Jewish women with ovarian cancer who have mutations in the BRCA1 or BRCA2 genes lived significantly longer than Ashkenazi Jewish ovarian cancer patients without these mutations. After up to nine years of follow-up, BRCA1/2 mutation carriers were 28 percent less likely to die from the disease, even though women with the BRCA mutations are significantly more likely to develop ovarian and breast cancers.
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2. Breast cancer risk varies significantly among BRCA1 and BRCA2 carriers
   01-08-2008 · EurekAlert!
   There is a broad variation in the risk of developing breast cancer among people who carry the BRCA1 and BRCA2 gene mutation, according to a study in the Jan. 9/16 issue of JAMA.
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3. Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations
   02-11-2008 · EurekAlert!
   The surgical removal of the ovaries has been widely adopted as a cancer-risk-reducing strategy for women with either BRCA1 or BRCA2 mutations. A new multicenter study led by researchers at Memorial Sloan-Kettering Cancer Center is the first prospective examination of the impact of this procedure in which BRCA2 mutation carriers were analyzed separately from BRCA1 mutation carriers.
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4. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
   12-25-2007 · EurekAlert!
   Among several US racial/ethnic groups examined, Hispanic women were found to have the highest prevalence of the cancer-associated gene mutation BRCA1 at 3.5 percent, with Asian Americans having the lowest prevalence (0.5 percent), according to a study in the Dec. 26 issue of JAMA.
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5. BRCA1 mutation linked to breast cancer stem cells
   01-31-2008 · EurekAlert!
   A new study may explain why women with a mutation in the BRCA1 gene face up to an 85 percent lifetime risk of breast cancer. Researchers from the University of Michigan Comprehensive Cancer Center found that BRCA1 plays a role in regulating breast stem cells, the small number of cells that might develop into cancers.
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6. Personalized medicine can cut breast cancer risk
   02-15-2008 · EurekAlert!
   The time has come for breast cancer risk assessment, counseling and genetic testing to move from cancer specialists to the realm of primary care. A growing body of evidence has documented the benefits of preventive measures for high-risk women including those with mutations in the BRCA1 and BRCA2 genes. Referral for cancer-risk assessment and BRCA testing in the primary care setting is a necessary step towards personalized medicine for women at risk.
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7. New clues to breast cancer development in high-risk women
   09-11-2007 · EurekAlert!
   Physicians who treat women with the breast cancer susceptibility gene BRCA1 often remove their patients' ovaries to eliminate the source of estrogen they believe fuels cancer growth. Yet they also know that anti-estrogen therapies don't work to treat breast or ovarian cancer that might develop. That paradox has led scientists to question exactly how, or if, estrogen is involved in cancer development and whether removal of ovaries makes sense.
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8. Family structure size could affect breast cancer risk prediction accuracy for BRCA gene testing
   06-19-2007 · EurekAlert!
   Researchers have found that the probability of the breast cancer gene mutation BRCA among women with a history of breast cancer is greater when the number of older, female relatives in the family is smaller, according to a study in the June 20 issue of JAMA. This finding may challenge the accuracy of some breast cancer prediction models, which may not take family structure into account.
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9. New pathway provides more clues about BRCA1 role in breast cancer
   01-15-2008 · EurekAlert!
   A breast cancer gene's newly discovered role in repairing damaged DNA may help explain why women who inherit a mutated copy of the gene are at increased risk for developing both breast and ovarian cancer.
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10. More common associations found between BRCA1 and BRCA2 mutations and cancer
    12-05-2006 · EurekAlert!
    BRCA1 and BRCA2 mutations may be more common in the general population than previously reported and may be associated with ovarian, breast, testicular and pancreatic cancers, according to a study in the Dec. 6 issue of the Journal of the National Cancer Institute.
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