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UT Southwestern researchers uncover mechanisms of common inherited mental retardation

Researchers at UT Southwestern Medical Center are uncovering how brain cells are affected in Fragile X syndrome, the most common cause of inherited mental retardation and the most common genetic cause of autism.

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Similar news on "UT Southwestern researchers uncover mechanisms of common inherited mental retardation":

1. Researchers uncover mechanisms of common inherited mental retardation
   01-08-2008 · UT Southwestern Medical Center
   Researchers at UT Southwestern Medical Center are uncovering how brain cells are affected in Fragile X syndrome, the most common cause of inherited mental retardation and the most common genetic cause of autism.
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2. How genetic malfunction causes a form of retardation
   04-18-2007 · EurekAlert!
   Researchers have discovered that the genetic malfunction that causes a form of mental retardation called Noonan Syndrome produces an imbalance in the genesis of two types of cells in the developing embryonic brain. This imbalance, they theorize, could explain how the genetic abnormality gives rise to the neural pathology of the disorder. More broadly, they said, the new insight into the mechanism underlying NS could apply to other inherited forms of retardation.
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3. MIT researchers reverse symptoms in mice of leading inherited cause of mental retardation
   06-25-2007 · EurekAlert!
   Researchers at the Picower Institute at MIT have, for the first time, reversed symptoms of mental retardation and autism in mice. The study may lead to new drug therapies for a leading inherited cause of mental retardation (Fragile X Syndrome) and some types of autism.
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4. Flawed Stem Cells Yield Fragile X Clues: Researchers study genetic disorder via discarded embryos
   11-17-2007 · Science News Online
   The most common inherited cause of mental retardation arises when a mutated gene is shut down early in embryonic development.
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5. Crucial progress in understanding Fragile X mental retardation protein
   06-06-2007 · EurekAlert!
   Researchers in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine have identified a new regulatory target for the Fragile X mental retardation protein, laying the groundwork for possible new treatments for Fragile X syndrome, the leading inherited form of mental retardation.
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6. MIT corrects inherited retardation, autism in mice
   12-19-2007 · Massachusetts Institute of Technology (MIT)
   Researchers at MIT's Picower Institute for Learning and Memory have corrected key symptoms of mental retardation and autism in mice. The work indicates that a certain class of drugs could have the same effect in humans.
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7. Fragile X retardation syndrome corrected in mice
   12-19-2007 · EurekAlert!
   Researchers working with mice have significantly alleviated a wide range of abnormalities due to fragile X syndrome by altering only a single gene, countering the effects of the fragile X mutation. They said their achievement offers the potential for treatment of the disorder, the most common form of inherited mental retardation and a leading identified genetic cause of autism. There is currently no treatment or therapy for fragile X syndrome, whose symptoms include mental retardation, epilepsy and abnormal body growth.
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8. Researchers reveal HIV peptide's possible pathway into the cell
   01-17-2008 · EurekAlert!
   Two theoretical physicists at Rensselaer Polytechnic Institute have uncovered what they believe is the long-sought-after pathway that an HIV peptide takes to enter healthy cells. The theorists analyzed two years of biocomputation and simulation to uncover a surprisingly simple mechanism describing how this protein fragment penetrates the cell membrane. The discovery could help scientists treat other human illnesses by exploiting the same molecules that make HIV so deadly proficient.
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9. Researchers uncover key interaction in cholesterol regulation
   02-04-2008 · EurekAlert!
   Researchers at UT Southwestern Medical Center have determined the specific way in which a destructive protein binds to and interferes with a molecule that removes low-density lipoproteins, the so-called "bad" cholesterol, from the blood.
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10. Rutgers scientists discover brain cell development process implicated in mental retardation
    07-31-2007 · EurekAlert!
    Scientists at Rutgers University have discovered a biological process in brain cell development that may help explain some causes of mental retardation. This understanding may one day help other researchers develop therapies that can reduce specific forms of retardation. Proteins of the Rho family, when excessively present in developing brain cells known as neurons, inhibit another protein, called cypin, that promotes healthy neuron development.
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