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Evolution of human genome's 'guardian' gives people unique protections from DNA damage

Evolution has given humans unique protections through the p53 regulatory network -- so-called guardian of the genome -- against DNA damage that could cause cancer or genetic diseases, according to a study led by Cincinnati Children's Hospital Medical Center in the Jan. 22 Proceedings of the National Academy of Sciences. Rodents do not have these same protections, creating the need for additional considerations when interpreting studies in rodent models.

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Keywords: evolution, human, genome, guardian, people, unique, protections, dna, damage, protection

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