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Engineered mice provide insight into Alzheimer's disease
01-17-2008 · EurekAlert!One factor that determines an individual's risk of developing Alzheimer's disease is the version of the APOE gene that they carry. It has been hypothesized that increasing the amount of fat associated with apoE by overexpressing ABCA1 might decrease amyloid deposition in the brain, the hallmark of AD. Support for this hypothesis has now been generated in mice, suggesting that increasing the function of ABCA1 in the brain might benefit individuals with AD.
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Keywords: engineered, mice, provide, insight, alzheimer, disease
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- JCI table of contents: Jan. 17, 2008
01-17-2008 · EurekAlert!
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Jan. 17, 2008, in the JCI: Engineered mice provide insight into Alzheimer disease; Scratching an itch: neutralizing IL-22 prevents psoriasis in mice; Seeing is believing: visualizing inflammation in fat tissue; and Factor I complements the kidney.
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- Mice with Alzheimer's disease suffer 'silent' seizures
09-05-2007 · EurekAlert!
Mice genetically engineered to have a disease like Alzheimer's have "silent" seizures that appear related to cellular changes involving the excess accumulations of the protein amyloid beta, said researchers from the Gladstone Institute of Neurological Disease and Baylor College of Medicine in a report that appears in today's issue of the journal Neuron.
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- Androgen therapy may slow progress of Alzheimer's disease
12-19-2006 · EurekAlert!
Experiments on mouse models of Alzheimer's disease suggest that treatment with male sex hormones might slow its progression. The findings, published in the Dec. 20 issue of the Journal of Neuroscience, provide new insight into the relationship between testosterone loss and AD, which affects 4.5 million Americans.
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- More insight into Alzheimer's disease with Stanford discovery of possible cause
11-20-2006 · EurekAlert!
Researchers at the Stanford University School of Medicine discovered that when a molecule responsible for dialing down the immune system malfunctions in the brain cells of mice, the rodents develop symptoms of the degenerative brain disease.
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- T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
09-18-2007 · EurekAlert!
Human white blood cells, engineered to recognize other malignant immune cells, could provide a novel therapy for patients with highly lethal B cell cancers such as acute lymphoblastic leukemia, according to researchers at Memorial Sloan-Kettering Cancer Center. By administering repeated doses of T cells designed to express an artificial receptor which recognizes human B cells, the researchers were able to eradicate cancer in 44 percent of mice bearing human ALL tumors.
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- Protein inhibitor tangles with Alzheimer's disease
02-15-2007 · EurekAlert!
A hallmark of Alzheimer's disease (AD) is the abnormal accumulation of phosphorylated forms of a protein known as tau. In a new study, Mayo Clinic researchers have now shown in mice that a drug that inhibits the function of the protein Hsp90 (EC102) reduces the amount of phosphorylated tau in the brain. Unlike many drugs, EC102 is able to cross the blood-brain barrier, making it a highly promising therapeutic candidate for AD.
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- Decreased TGF-beta signaling might make you demented
11-01-2006 · EurekAlert!
The physical changes that occur in the brain of patients with Alzheimer's disease, the most common cause of dementia in the elderly, have been well-characterized, but the cause(s) of this disease and the development of therapies has remained elusive. A new study now shows that decreased signaling through a receptor known as T-beta-RII -- expression of which is decreased in the neurons of patients with AD -- increases neurodegeneration in mice.
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- A possible mechanistic link between stress and the development of Alzheimer tangles
06-14-2007 · EurekAlert!
Subjecting mice to repeated emotional stress, the kind we experience in everyday life, may contribute to the accumulation of neurofibrillary tangles, one of the hallmarks of Alzheimer’s disease, report researchers at the Salk Institute for Biological Studies.
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- Transdermal vaccine effective in treating Alzheimer's disease in mouse model
01-22-2007 · EurekAlert!
A novel needle-free vaccine approach was found safe and effective in clearing brain-damaging plaques from mice bred to develop Alzheimer's disease. The transdermal vaccination may offer a simple, noninvasive way of preventing or treating Alzheimer'swith less potential for adverse immune reactions.
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- Altering brain's lipid metabolism reduces Alzheimer's plaques in mice
01-17-2008 · EurekAlert!
Increasing levels of a protein that helps the brain use cholesterol may slow the development of Alzheimer's disease changes in the brain, according to researchers studying a mouse model of the disease at Washington University School of Medicine in St. Louis.
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