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Engineering chimeric polypeptides to illuminate cellular redox states
01-23-2008 · EurekAlert!An interdisciplinary research team from the University of Illinois' Institute for Genomic Biology reports the design of chimeric redox-sensitive polypeptides as the first step towards development of the FRET-based biosensors for visualizing redox potentials and oxidative stress in live cells via optical microscopy. The FRET-based biosensors are a significant advance for routinely measuring oxidative stress in real time. They promise to be broadly applicable by biomedical researchers working in diverse fields of cellular biology.
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Keywords: engineering, chimeric, polypeptides, illuminate, cellular, redox, states, polypeptide, state
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