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Penn researchers discover new target for preventing and treating flu
01-30-2008 · EurekAlert!Researchers at the University of Pennsylvania School of Medicine have now provided a new strategy for designing drugs that target resistant viral strains of inflenza tupe A by solving the three-dimensional structure of a viral protein called the M2 proton channel. This protein is the molecular receptor for these drugs.
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- Penn researchers find potential new target for Type 2 diabetes
06-08-2007 · EurekAlert!
Researchers at the University of Pennsylvania School of Medicine have discovered a potential new target for treating type 2 diabetes. The target is a protein, along with its molecular partner, that regulates fat metabolism.
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- Emory researchers identify signaling protein for multiple myeloma
09-10-2007 · EurekAlert!
Researchers at Emory University's Winship Cancer Institute are the first to discover a mechanism that plays a critical role in the multiple myeloma cell cycle and survival. Their research may result in identification of a new therapeutic target for treating multiple myeloma.
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- Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment
04-18-2007 · EurekAlert!
Researchers at the University of Pennsylvania School of Medicine have discovered that an enzyme produced by lung-infecting bacteria further shuts down a protein that is defective in cystic fibrosis patients. The disruption to this protein that conveys ions from lung cells to airways causes thick mucus to buildup inside the lung. The finding suggests a new therapeutic target for treating lung infections in some cystic fibrosis patients.
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- Penn researchers discover novel pathway for increasing 'good' cholesterol
08-08-2007 · EurekAlert!
Researchers have discovered that a group of liver enzymes may be the key to raising levels of good cholesterol. The pathway by which these proteins are able to achieve an increase in HDL cholesterol involves another enzyme that normally degrades HDL-C. The newly recognized relationship between these enzymes and cholesterol represents another target for ultimately controlling good cholesterol.
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- Penn research shows transcranial magnetic stimulation effective in treating major depression
11-26-2007 · EurekAlert!
Researchers at the University of Pennsylvania School of Medicine and other study sites have found that transcranial magnetic stimulation -- a noninvasive technique that excites neurons in the brain via magnetic pulses passed through the scalp -- is a safe and effective, nondrug treatment with minimal side effects for patients with major depression who have tried other treatment options without benefit.
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- Scientists reveal secrets of Homer's Cyclops to help people with Holoprosencephaly
01-17-2007 · EurekAlert!
Scientists from Cleveland, Ohio, and Paris, France, reached an important milestone in understanding a molecular cause of a rare, but serious birth defect, Holoprosencephaly. In this February's FASEB Journal, researchers explain why and how some fetal brains fail to develop two lobes, as well as why and how the related skull and facial defects occur. Information from this study will enable researchers to pursue better approaches toward detecting, preventing, and treating this serious disorder.
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- Extra cortisol protects women's mood under stress
02-11-2007 · EurekAlert!
German researchers have found additional evidence that the stress hormone cortisol can have positive effects in certain situations. Although chronic stress, which brings long-term elevations of cortisol in the bloodstream, can weaken the immune system and induce depression, this new study adds to mounting evidence that cortisol given near in time to a physical or psychological stress may lessen the stressor's emotional impact. Psychologists are especially interested in what this means for preventing and treating post-traumatic stress disorder.
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- Penn researchers discover new mechanism for viral replication
08-16-2007 · EurekAlert!
Researchers have identified a new strategy that Kaposi's Sarcoma Associated Herpesvirus uses to dupe infected cells into replicating its viral genome. This is the first study to directly show that a section of viral DNA can independently draw upon proteins within a host cell to promote its own replication.
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- New tool to shed light on, improve teen mental health services
05-15-2007 · EurekAlert!
Can you imagine an archer trying to improve her accuracy by practicing blindfolded, never seeing how close she was to hitting her target? Until now, those treating teens with mental health concerns were in the same position as that blindfolded archer, providing services with no objective and systematic feedback about the effects. A new tool developed by Vanderbilt University researchers will remove that blindfold.
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- Semen ingredient 'drastically' enhances HIV infection
12-13-2007 · EurekAlert!
A plentiful ingredient found in human semen drastically enhances the ability of the human immunodeficiency virus (HIV) to cause infection, according to a report in the Dec. 14, 2007, issue of the journal Cell, a publication of Cell Press. The findings help to understand the sexual transmission of HIV and suggest a potential new target for preventing the spread of AIDS, the researchers said.
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