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Breaking down Huntington's disease one protein at a time
02-04-2008 · EurekAlert!Hoping to piece together the intricate series of interactions that lead to Huntington's disease, Indiana University Bloomington scientists have determined the shape and structure of a binding site that may prove useful in combating the neurodegenerative disease.
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Keywords: breaking, down, huntington, disease, protein, time
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- Mayo discovers link between Huntington's and abnormal cholesterol levels in brain
12-01-2006 · EurekAlert!
Mayo Clinic researchers have discovered a protein interaction that may explain how the deadly Huntington's disease affects the brain. The findings, published in and featured on the cover of the current issue of Human Molecular Genetics, show how the mutated Huntington's protein interacts with another protein to cause dramatic accumulation of cholesterol in the brain.
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- Batten down the hatches against HIV
02-20-2007 · EurekAlert!
A promising approach to gene therapy involves short DNA fragments (interfering RNA) that bind to specific genes and block their "translation" into the corresponding, disease-related protein. A stumbling block has been the efficient and targeted delivery of RNA into the cells. Researchers led by Hongjie Dai at Stanford University have sucessfully used carbon nanotubes as a "means of transport," they write in "Angewandte Chemie."
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- Insect attack may have finished off dinosaurs
01-02-2008 · EurekAlert!
Asteroid impacts or massive volcanic flows might have occurred around the time dinosaurs became extinct, but a new book argues that the mightiest creatures the world has ever known may have been brought down by a tiny, much less dramatic force -- biting, disease-carrying insects.
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- JCI table of contents: February 15, 2006
02-15-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, February 15, 2006, in the JCI, including: Protein inhibitor tangles with Alzheimer's disease; Proteases cause pain in irritable bowel syndrome; The "shear stress" of it impacts heart disease; Blood pressure heads down in the absence of PPAR-gamma; and Profiling peripheral T cell lymphoma for clues to its pathogenesis.
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- New York City death rate reaches historic low
01-08-2008 · EurekAlert!
The death rate in New York City reached an all-time low in 2006, as the number of deaths fell to 55,391 -- down from 57,068 in 2005 and 60,218 in 2001. Mortality declined in eight leading categories, including diabetes, HIV, chronic lung disease and kidney failure. The only leading killer that increased significantly was substance use (up 8 percent).
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- New cause identified for necrotic enteritis in chicken
02-07-2008 · EurekAlert!
Researchers from Monash University and CSIRO Livestock Industries have demonstrated for the first time that alpha-toxin protein, long thought to be required for necrotic enteritis to develop, is not the main cause of the chicken disease. The study, published Feb. 8 in the open-access journal PLoS Pathogens, provides insight into one of the world's most common and financially crippling poultry diseases.
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- Scripps research study reveals structural dynamics of single prion molecules
02-12-2007 · EurekAlert!
Using a combination of novel technologies, scientists at the Scripps Research Institute and the Whitehead Institute for Biomedical Research have revealed for the first time a dynamic molecular portrait of individual unfolded yeast prions that form the compound amyloid, a fibrous protein aggregate associated with neurodegenerative diseases such as Alzheimer's disease and variant Creutzfeldt-Jacob disease -- the human version of mad cow disease.
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- Huntington's disease problem start early
01-09-2008 · EurekAlert!
The damaging effects of the mutated protein involved in Huntington's disease take place earlier in cell life than previously believed, said researchers from Baylor College of Medicine in Houston in a report that appears in the current edition of the journal Neuron.
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- Study suggests new treatments for Huntington's disease
01-09-2008 · EurekAlert!
Working with fruit flies, researchers have discovered a new mechanism by which the abnormal protein in Huntington's disease causes neurodegeneration. They have also manipulated the flies to successfully suppress that neurodegeneration, which they said suggests potential treatments to delay the onset and progression of the disease in humans.
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- Mitochondrial 'bottleneck' cracked
01-27-2008 · EurekAlert!
Scientists have shown for the first time how a particular family of diseases are passed down from mother to child and how this can lead to the severity of the disease differing widely. The research, funded by the Wellcome Trust, offers hope of being able to predict a child's risk of developing a mitochondrial disease which can cause muscle weakness, diabetes, strokes, heart failure and epilepsy.
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