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Calcium aids protein folding as therapy for enzymes in types of lysosomal storage diseases
02-04-2008 · EurekAlert!By adapting the protein homeostasis network, altering calcium homeostasis can restore the cell's ability to fold and traffic proteins prone to misfolding, offering a new strategy to ameliorate loss-of-function diseases.
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Keywords: calcium, aids, protein, folding, therapy, enzymes, types, lysosomal, storage, diseases, aid, enzyme, type, disease
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- Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
02-04-2008 · EurekAlert!
Scientists at the Scripps Research Institute have discovered that two widely available prescription drugs restore partial cellular folding, trafficking, and function to a variety of mutant enzymes responsible for three distinct lysosomal storage diseases, maladies involving multiple organ system failure.
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- Penn researchers discover new molecular path to fight autoimmune diseases
03-06-2007 · EurekAlert!
Multiple sclerosis, diabetes, and arthritis are among a variety of autoimmune diseases that are aggravated when one type of white blood cell, called the immune regulatory cell, malfunctions. In humans, one cause of this malfunction is when a mutation in a gene called FOXP3 disables the immune cells’ ability to function. Penn researchers have discovered how to modify enzymes that act on the FOXP3 protein, in turn making the regulatory immune cells work better.
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- Model aids understanding of protein networks
06-25-2007 · Massachusetts Institute of Technology (MIT)
An international team of researchers, including several from MIT, have developed a model that could help researchers understand the complex protein networks that influence human disease, including cancer. The model helps identify relationships between proteins and regulatory enzymes.
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- Enzyme structure reveals new drug targets for cancer and other diseases
02-14-2008 · EurekAlert!
Researchers now have a clearer understanding of how a key protein controls gene activity and how mutations in the protein may cause disease. The work could provide new avenues to design drugs aimed at cancer, diabetes, HIV, and heart disease.
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- A transplant in time
12-28-2006 · EurekAlert!
In hemophilia, a mutated gene prevents the production of a blood-clotting protein. Treatments for hemophilia and other genetic diseases may consist of risky blood transfusions or expensive enzyme replacement therapy. But what if the body could be induced to begin producing these proteins by transplanting healthy tissue with the abilities that are lacking? The Weizmann Institute's Immunology Department showed how such a transplant might be made feasible.
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- Antibody-altering protein found in developing B cells
07-19-2007 · EurekAlert!
AID is an antibody-altering protein, originally thought to be made onlyby mature B cells and in the developing B cells of transgenic mice.Researchers at Tufts University report that AID is also made bydeveloping B cells in wild-type, or normal, mice. This may offer a newdirection for research into autoimmune diseases.
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- Pregnancy may slow -- not accelerate -- progression to AIDS
09-19-2007 · EurekAlert!
A new study may help put to rest fears that pregnancy accelerates progression to full-blown AIDS in women with HIV receiving antiretroviral therapy. The study, published in the Oct. 1 issue of the Journal of Infectious Diseases and now available online, revealed that pregnancy may, in fact, slow disease progression in these women.
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- More aid required for chronic conditions in low income countries
01-17-2007 · EurekAlert!
Chronic conditions such as cardiovascular disease and cancer result in more deaths and account for more years of healthy life lost than most communicable diseases, and yet little international aid is focused on preventing or treating these conditions. Cardiovascular disease causes 30 percent of all deaths globally and 27 percent of deaths in low income countries. By comparison, HIV/AIDS, tuberculosis and malaria, combined, account for 10 percent of all deaths globally and 11 percent of death in developing countries.
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- Combination therapy stops loss of kidney function in rare genetic disease
07-25-2007 · EurekAlert!
A combination of two types of blood pressure-lowering drugs -- an angiotensin-converting enzyme inhibitor (ACEI) plus an angiotensin-receptor blocker (ARB), added to enzyme replacement therapy (ERT) with agalsidase-beta (Fabrazyme, Genzyme Corporation, Cambridge, Mass.) -- is the first treatment shown to stop progressive loss of kidney function in patients with severe kidney involvement due to the rare genetic disorder Fabry disease, reports a study in the September Journal of the American Society of Nephrology.
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- Brown team finds crucial protein role in deadly prion spread
01-23-2007 · EurekAlert!
Brown University biologists have made another major advance toward understanding the deadly work of prions, the culprits behind fatal brain diseases such as mad cow and their human counterparts. In new work published online in PLoS Biology, researchers show that the protein Hsp104 must be present and active for prions to multiply and cause disease.
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