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Gene found to play a suppressor role in skin cancer development

Researchers at the Burnham Institute for Medical Research have provided genetic evidence that Activating Transcription Factor 2 plays a suppressor role in skin cancer development. ATF2 is a protein that regulates gene transcription, the first step in the translation of genetic code, in response to extracellular stresses such as ultraviolet light and ionizing radiation. This function of ATF2 in stress and DNA damage response suggests it may also play a role in tumor formation.

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Keywords: gene, play, suppressor, role, skin, cancer, development

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   An important cancer-related gene may play a critical role in the development of the placenta, the organ that controls nutrient and oxygen exchange between a mother and her fetus during pregnancy, and perhaps in miscarriages. Those conclusions come from a new study of the retinoblastoma (Rb) gene in mice. In humans, this gene, when mutated, raises the risk of a rare cancer of the eye called retinoblastoma.
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2. Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
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3. Pioneering study looks at p53’s Role in tumor-stroma interactions
   10-25-2006 · EurekAlert!
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4. Pioneering study looks at p53's role in tumor-stroma interactions
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5. Zebrafish: It's not your parents' lab rat
   07-30-2007 · EurekAlert!
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   10-15-2006 · EurekAlert!
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