Daily non-political popular news in brief.
Gene plays 'Jekyll and Hyde' in brain cancer
02-06-2008 · EurekAlert!Researchers have found that a particular gene is central to the brain cancer glioblastoma and will either fight the tumor or, conversely, help the tumor advance, depending on the tumor's genetic makeup.
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Keywords: gene, plays, jekyll, hyde, brain, cancer, play
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- Gene found to play a suppressor role in skin cancer development
02-06-2008 · EurekAlert!
Researchers at the Burnham Institute for Medical Research have provided genetic evidence that Activating Transcription Factor 2 plays a suppressor role in skin cancer development. ATF2 is a protein that regulates gene transcription, the first step in the translation of genetic code, in response to extracellular stresses such as ultraviolet light and ionizing radiation. This function of ATF2 in stress and DNA damage response suggests it may also play a role in tumor formation.
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- Cold sore virus might play role in Alzheimer's
01-03-2007 · EurekAlert!
A gene known to be a major risk factor for Alzheimer's disease puts out the welcome mat for the virus that causes cold sores, allowing the virus to be more active in the brain compared to other forms of the gene. The findings add some scientific heft to the idea, long suspected by some scientists, that herpes somehow plays a role in bringing about Alzheimer's disease.
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- Zebrafish: It's not your parents' lab rat
07-30-2007 · EurekAlert!
Developmental biologists at Rice University have found that a gene called LMO4, which is known to play roles in both cell reproduction and in breast cancer, also plays a role in neurological development. By both knocking out and overexpressing the gene in zebrafish, the scientists determined that LMO4 independently regulates two other genes that are involved with the development of the forebrain and eyes. The results are slated to appear in the journal Developmental Biology.
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- 'Gateway' gene discovered for brain cancer
02-14-2007 · EurekAlert!
Researchers have discovered that the same genetic regulator that triggers growth of stem cells during brain development also plays a central role in the development of the lethal brain cancer malignant glioma. In experiments on mice with such gliomas, they showed that knocking out the function of a particular regulatory protein, Olig2, almost completely eliminated tumor formation.
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- Cold sore virus might play role in Alzheimer's disease
01-03-2007 · EurekAlert!
A gene known to be a major risk factor for Alzheimer's disease puts out the welcome mat for the virus that causes cold sores, allowing the virus to be more active in the brain compared to other forms of the gene. The findings add some scientific heft to the idea, long suspected by some scientists, that herpes somehow plays a role in bringing about Alzheimer's disease.
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- Tumor-suppressor gene is critical for placenta development
01-09-2007 · EurekAlert!
An important cancer-related gene may play a critical role in the development of the placenta, the organ that controls nutrient and oxygen exchange between a mother and her fetus during pregnancy, and perhaps in miscarriages. Those conclusions come from a new study of the retinoblastoma (Rb) gene in mice. In humans, this gene, when mutated, raises the risk of a rare cancer of the eye called retinoblastoma.
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- Inflammation may play role in metastasis of prostate cancer
03-18-2007 · EurekAlert!
Research at the UCSD School of Medicine strongly suggests that inflammation associated with the progression of tumors actually plays a key role in the metastasis of prostate cancer.
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- Preclinical study links gene to brain aneurysm formation
08-07-2007 · EurekAlert!
University of Cincinnati neurovascular researchers have identified a gene that -- when suppressed or completely absent -- may predispose a person to brain aneurysms. Todd Abruzzo, MD, and his colleagues demonstrated that "knocking out" a gene known as endothelial nitric oxide synthase in an animal model led to intracranial aneurysm formation in 33 percent of study subjects. Scientists say this suggests that the gene may play an important role in the development of intracranial aneurysms.
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- Pioneering study looks at p53’s Role in tumor-stroma interactions
10-25-2006 · EurekAlert!
Researchers have conducted the first comprehensive study of the role an important tumor suppressor gene plays in cancer development. P53 is known as a major tumor suppressor that is frequently mutated in human cancer. In this study, researchers used novel proteomic techniques to identify the proteins secreted by cells specifically in response to p53. The findings suggest a newfound role for wt-p53 in the control of the tumor's ability to communicate with the normal stromal cells surrounding it.
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- Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
11-01-2006 · EurekAlert!
Cell biologists have provided further evidence that a gene thought to play a role in suppressing tumors actually protects against the development of pre-cancerous cell growth as well. The researchers say that the gene, caveolin-1, which they found in two major types of breast cells, could be a potential target for future drugs aimed at preventing breast cancer. The work also suggests a potentially important role of the tumor "microenvironment" in the cancerous process.
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