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VEGF-B helps nerve cells cheat death without unwanted side effects
02-07-2008 · EurekAlert!The prototypical member of the VEGF family of proteins, VEGF, protects cells in the nervous system from death and degeneration. However, its clinical utility in this regard is limited, because it also induces blood vessel growth, a process known as angiogenesis. However, a new study has revealed that another VEGF family member, VEGF-B, does not have such limitations as it acts as a potent inhibitor of murine retinal cell death while exerting minimal angiogenic effects.
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Keywords: vegf-b, nerve, cells, cheat, death, unwanted, side, effects, vegf, cell, effect
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- JCI online early table of contents: Feb. 7, 2008
02-07-2008 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Feb. 7, 2008, in the JCI, including: VEGF-B helps nerve cells cheat death without unwanted side effects; The key to survival and virulence for a fungal pathogen is autophagy; Straight to the tumor: fusion protein targets iNKT immune cells to tumors; T cells stopped from reaching their destination; The soluble factor IL-10 has guts: and others.
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- Immunosuppressive drugs are a double-edged sword to type 1 diabetics
09-04-2007 · EurekAlert!
Type 1 diabetes occurs when immune cells destroy pancreatic insulin producing beta-cells. It was hoped that islet transplantation would provide a cure for the disease, however, transplant success is short-lived and accompanied by significant side effects. New data indicate that the immunosuppressive drugs used to prevent islet transplant rejection suppress beta-cell regeneration in diabetic mice, raising the possibility that identifying immunosuppressive drugs that do not inhibit beta-cell regeneration might lead to successful regenerative islet transplantation.
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- Atrogin breaks down the side effects of statins
11-08-2007 · EurekAlert!
Statins are a popular class of drugs used to successfully combat high cholesterol. However, the rare, but serious, and poorly understood side effect of skeletal muscle breakdown prevents more prevalent use of these drugs. New research in mice has now indicated that atrogin-1 is a critical mediator of statin-induced muscle damage and that inhibiting atrogin-1 function might protect against this unwanted side effect of statins.
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- Epilepsy-induced brain cell damage prevented in the laboratory
10-29-2007 · EurekAlert!
For some epilepsy patients, the condition's side effects can be as troubling as the seizures. One pressing concern is potential cognitive impairment from seizures, which can include memory loss, slowed reactions and reduced attention spans. Now researchers have linked such cognitive impairments to structural changes in brain cells caused by seizures. They report that the insights they gained allowed them to use a drug to block those changes in the brains of laboratory animals.
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- Researchers propose reason for severe side-effects of Northwick Park clinical trial
01-25-2007 · EurekAlert!
A possible reason why the Northwick Park clinical trial of the drug TGN1412 in the UK caused multiple organ failure in human volunteers is revealed in research presented today at a conference near Paris. The research shows that stimulating the molecule CD28 on cells that mediate the immune response, known as T cells, can have an adverse effect if these immune cells have been activated and altered by infection or illness in the past.
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- Penn researchers identify new combination therapy that promotes cancer cell death
07-16-2007 · EurekAlert!
To test the ability of combined therapy, researchers administered TRAIL, a tumor necrosis factor, and sorafenib, an inhibitor currently used to treat renal cancer, to mice with colon carcinomas. It reduced the size of tumors in mice with few side effects
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- Ireland Cancer Center researchers advance stem cell gene therapy
12-12-2007 · EurekAlert!
Ireland Cancer Center of University Hospitals Case Medical Center researchers recently made great strides in stem cell gene therapy research by transferring a new gene to cancer patients, via their own stem cells, with the ultimate goal of being able to use stronger chemotherapy treatment with less severe side effects. This is the first time selection of this gene has been shown to occur in patients.
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- Inside job: new radioactive agents for colon cancer work inside cells
10-09-2007 · EurekAlert!
Johns Hopkins scientists have developed a potentially novel way to fight colorectal cancer using tiny molecules to deliver potent barrages of radiation inside cancer cells, unlike current treatments that bind to the surface of cells and attack from the outside and cause unwanted side effects.
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- How 'IAP antagonist' chemicals kill tumors
11-15-2007 · EurekAlert!
Chemical compounds specially designed to neutralize proteins that would otherwise allow tumor cells to cheat death have been recognized for some time by scientists as a promising new avenue for cancer therapy. Now, two studies in the Nov. 16, 2007 issue of the journal Cell, a publication of Cell Press, provide insight into just how these antagonists of the anti-death -- so-called Inhibitor-of-Apoptosis (IAP) -- proteins work to fight tumors.
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- Nanomedicine opens the way for nerve cell regeneration
05-20-2007 · EurekAlert!
The ability to regenerate nerve cells in the body could reduce the effects of trauma and disease in a dramatic way. In two presentations at the NSTI Nanotech 2007 Conference, researchers describe the use of nanotechnology to enhance the regeneration of nerve cells.
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