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Oregon researchers discover a mechanism leading to cleft palate

02-11-2008 · EurekAlert!

By creating a genetic mutation in zebrafish, University of Oregon scientists say they've discovered a previously unknown mechanism for cleft palate, a common birth defect in humans that has challenged medical professionals for centuries.

Keywords: oregon, researchers, discover, mechanism, leading, cleft, palate, researcher

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UBC researchers discover 'instruction manual' that tells cancers how to hide from immune system
11-08-2007 · EurekAlert!
A mechanism that creates an "invisibility cloak" for certain cancer cells and allows them to hide from the immune system has been uncovered by a team of researchers at the University of British Columbia.
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Gene involved in common birth defect also regulates skin biology
10-15-2006 · EurekAlert!
Following up on an earlier discovery that a gene called IRF6 is involved in the common birth defect cleft lip and palate, University of Iowa researchers and their colleagues have identified the function of the gene. Their latest findings, published online Oct. 15 in Nature Genetics, reveal an unexpected role for IRF6 in the growth and development of skin cells, a discovery that may have implications for wound healing and cancer research.
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Einstein researchers discover how a key dietary vitamin is absorbed
11-30-2006 · EurekAlert!
Researchers at the Albert Einstein College of Medicine of Yeshiva University have found the mechanism by which the B vitamin folate -- a crucially important nutrient -- is absorbed by the intestinal tract. Their findings solve a longstanding mystery as to how folates in the diet are absorbed and pave the way for a genetic test that can save the lives of infants who lack the ability to absorb folate.
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Researchers discover protein that controls bone growth
12-19-2007 · EurekAlert!
A research team led by Dr. Pierre Moffatt of the Shriners Hospital for Children in Montreal and McGill University's Department of Human Genetics has uncovered the molecular mechanism by which the protein osteocrin controls bone growth -- a discovery that may have important implications for people suffering from bone diseases affecting skeletal growth. The team's findings appear in the Dec. 14 edition of the Journal of Biological Chemistry.
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Researchers discover inherited mutation for leukemia
05-31-2007 · EurekAlert!
Researchers have discovered the first inherited gene mutation that increases a person's risk for chronic lymphocytic leukemia, one of the most common forms of the disease. The study shows that the inherited mutation greatly reduces the gene's protective activity. Furthermore, a second kind of change occurs later that turns the gene off altogether, leading to leukemia. This latter alteration is a chemical change that is not inherited.
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Researchers discover discrepancies between dysphagia diet guidelines and prepared foods
10-24-2007 · EurekAlert!
Research at Wake Forest University Baptist Medical Center is leading to potentially lifesaving changes for patients suffering from dysphagia, or swallowing difficulty. Dysphagia is common among critical care patients and can lead to malnutrition, aspiration of food or liquids into the trachea, and pneumonia.
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Einstein researchers discover important clue to the cause of Parkinson's disease
01-02-2008 · EurekAlert!
A glitch in the mechanism by which cells recycle damaged components may trigger Parkinson's disease, according to a study by scientists at the Albert Einstein College of Medicine of Yeshiva University. The research, which appears in the Jan. 2 advance online issue of the Journal of Clinical Investigation, could lead to new strategies for treating Parkinson's and other neurodegenerative diseases.
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Bridging the Divide? Technique sheds light on cleft palate gene
02-17-2007 · Science News Online
A new approach has enabled researchers to prevent cleft palate in mice genetically engineered to develop that birth defect.
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OHSU Cancer Institute researcher discovers what fuels certain cancer mutation
12-10-2007 · EurekAlert!
An Oregon Health & Science University Cancer Institute researcher has discovered that a particular hormone is responsible for driving a cancer enzyme to cause an often deadly red blood cell cancer. Researchers working with the cancer mutation in the JAK2 enzyme have found that the enzyme is dependent on the hormone TNF-alpha to grow and cause a red blood cell cancer called polycythemia vera, said principal investigator Thomas Bumm, M.D., Ph.D., OHSU Cancer Institute member.
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New genetic mutations found that may cause cleft lip/palate
03-05-2007 · EurekAlert!
University of Iowa researchers and collaborators have identified new genetic mutations that likely cause the common form of cleft lip and palate. The results could eventually help clinicians predict a family's risk of having more children with the condition. The findings appear in the week of March 5 online Early Edition of the Proceedings of the National Academy of Sciences.
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