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Role identified for glaucoma gene and related signaling pathway
02-14-2008 · EurekAlert!Researchers have found that a gene and a related signaling pathway play a role in the development of glaucoma, which is a common cause of visual impairment and blindness worldwide. The study, which revealed that over-expression of the gene, sFRP1, elevates pressure in the eye, could help improve glaucoma diagnosis and lead to the development of sight-saving treatments.
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Keywords: role, identified, glaucoma, gene, related, signaling, pathway
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Increased pressure in the eye is a major risk factor for glaucoma, one of the main causes of visual impairment and blindness in the world. It is thought that impaired outflow of fluid from the eye causes glaucoma-associated increased pressure in the eye, and the authors of a new study have now shown that increased expression of the protein sFRP-1, an inhibitor of cell signaling through WNT proteins, seems to be responsible for this.
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