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Breast Cancer Findings Suggest New Ways To Detect And Destroy Cells Before They Become Cancerous
10-10-2006 · ScienceDailyNew UC Davis research supports the recent hypothesis that both ductal carcinoma in situ and invasive breast cancer develop from the same breast cancer progenitor cells.
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Keywords: breast, cancer, findings, suggest, ways, detect, destroy, cells, cancerous, finding, way, cell, cancerou
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- Study shows liver an excellent target for cancer gene therapy using viral vectors
02-14-2007 · EurekAlert!
A featured paper in the Feb. 14 issue of Nature Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells. The findings signal a new way to treat cancers that have spread to the liver, such as metastatic cancers of the colon and breast.
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- Why cisplatin kills breast cancer cells when other drugs fail
04-19-2007 · EurekAlert!
The cancerous cells of some individuals with breast cancer lack expression of two cell surface proteins, the estrogen and progesterone receptors, and do not express increased amounts of HER2. Individuals with such breast cancer (known as triple-negative breast cancer) do not respond to treatment with commonly used chemotherapeutic drugs and their prognosis is relatively poor. But a new study has indicated why triple-negative breast cancer cell lines are sensitive to exposure to the chemotherapeutic cisplatin.
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- Cancer cells enlist adult stem cells to promote metastasis
10-31-2007 · Massachusetts Institute of Technology (MIT)
MIT and Whitehead institute scientists have managed to facilitate metastasis, finding evidence that some breast cancer cells recruit normal adult stem cells from bone marrow and force them to secrete a protein that fosters cancer cell movement and invasion.
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- A faster way to recover from chemotherapy and marrow transplant
06-20-2007 · EurekAlert!
Researchers at Children's Hospital Boston report finding a practical way to increase stem cells in blood, suggesting a possible treatment to help patients recover from chemotherapy or bone marrow transplant for cancer, regaining immune function more quickly. The discovery, reported in the June 21 Nature and made possible through high-volume drug screening in fish, marks the first time stem-cell production has been induced by a small-molecule drug.
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- Knocking out survival protein could aid leukemia treatment
04-20-2007 · EurekAlert!
An effective way to fight leukemia might be to knock out a specific protein that protects cancer cells from dying, a new study shows. The findings suggest that a drug that can block this "survival protein" might on its own be an effective therapy.
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- MicroRNA regulates cancer stem cells
12-13-2007 · EurekAlert!
Researchers have discovered a key molecular switch that regulates cancer stem cells. This switch, which belongs to a class of molecules called microRNAs, can decrease a cancer stem cell's ability to propagate tumors. These findings offer a way for targeting cancer stem cells directly, and as a result open up new avenues for potentially treating cancer as a whole.
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- Researchers identify genetic mutation that may alter tumor cell proliferation
07-04-2007 · EurekAlert!
Researchers from Eli Lilly & Company and the Phoenix-based Translational Genomics Research Institute today announced finding a novel recurring mutation of the gene AKT1 in breast, colorectal and ovarian cancers. The altered form of AKT1 appears to cause tumor cell proliferation and may play a role in making cells resistant to certain types of therapies. The findings are reported in an advance online publication of the journal Nature.
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- Ancient mechanism for coping with stresses also gives cancer a boost
09-20-2007 · EurekAlert!
An ancient mechanism for coping with environmental stresses, including heat and toxic exposures, also helps cancerous tumors survive, reveals a new report in the Sept. 21, 2007, issue of Cell, a publication of Cell Press. The findings could lead to a new way to treat cancer and may also have implications for the treatment of neurodegenerative and other diseases, according to the researchers.
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- Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
11-01-2006 · EurekAlert!
Cell biologists have provided further evidence that a gene thought to play a role in suppressing tumors actually protects against the development of pre-cancerous cell growth as well. The researchers say that the gene, caveolin-1, which they found in two major types of breast cells, could be a potential target for future drugs aimed at preventing breast cancer. The work also suggests a potentially important role of the tumor "microenvironment" in the cancerous process.
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- Enzyme alerts cell's powerful army to repair DNA damage
09-05-2007 · EurekAlert!
Each day cells detect and repair daily assaults to our DNA. University of Michigan researchers have discovered that a well-known enzyme scans genes for damage and alerts the major cancer suppressor protein p53. The finding has implications for treating cancer and neurological diseases.
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