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New data from NIH lab confirms protocol to reverse type 1 diabetes in mice
11-23-2006 · EurekAlert!New data published in the Nov. 24 issue of Science provide further support for a protocol to reverse type 1 diabetes in mice and new evidence that adult precursor cells from the spleen can contribute to the regeneration of beta cells.
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Keywords: data, nih, lab, confirms, protocol, reverse, type, diabetes, mice, confirm, diabete
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- Immunosuppressive drugs are a double-edged sword to type 1 diabetics
09-04-2007 · EurekAlert!
Type 1 diabetes occurs when immune cells destroy pancreatic insulin producing beta-cells. It was hoped that islet transplantation would provide a cure for the disease, however, transplant success is short-lived and accompanied by significant side effects. New data indicate that the immunosuppressive drugs used to prevent islet transplant rejection suppress beta-cell regeneration in diabetic mice, raising the possibility that identifying immunosuppressive drugs that do not inhibit beta-cell regeneration might lead to successful regenerative islet transplantation.
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- Antibody therapy prevents type 1 diabetes in mice
01-08-2007 · EurekAlert!
University of Pittsburgh investigators have successfully prevented the onset of type 1 diabetes in mice prone to developing the disease using an antibody against a receptor on the surface of immune T-cells. According to the investigators, these findings, which are being published in the January issue of the journal Diabetes, have significant implications for the prevention of type 1 diabetes.
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- Cancer and arthritis therapy may be promising treatment for diabetes
12-18-2007 · EurekAlert!
An antibody used to treat certain cancers and arthritis also greatly delays type 1 diabetes in mice.
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- New data show ACTOS (pioglitazone HCl) halted progression of atherosclerosis as indicated by CIMT
11-13-2006 · EurekAlert!
Researchers today presented data showing that ACTOS (pioglitazone HCl) halted the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT) in patients with type 2 diabetes. Results from the clinical trial, CHICAGO (Carotid intima-media thickness in Atherosclerosis using pioglitazone), are part of a late-breaker presentation at the American Heart Association's Scientific Sessions 2006, coincidentally being held in Chicago, and coincide with an early online issue of the Journal of the American Medical Association.
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- New technique to 'see' and protect transplants successful in diabetic animal model
07-29-2007 · EurekAlert!
Researchers at Johns Hopkins have found a way to overcome a major stumbling block to developing successful insulin-cell transplants for people with type I diabetes. They developed a new technique encapsulates the insulin-producing cells in magnetic capsules, using an FDA-approved iron compound with an off-label use, which can be tracked by magnetic resonance imaging (MRI). The product, tested in swine and diabetic mice, also simultaneously avoids rejection by the immune system, likely a major reason for transplant failure.
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- MiniBooNE findings clarify the behavior of neutrinos
04-11-2007 · EurekAlert!
The initial data from the 10-year-long "MiniBooNE" experiment at the Department of Energy's Fermilab significantly clarifies the overall picture of how the neutrino fundamental particles behave. Designed to confirm or refute surprising observations from LSND experiments in the 1990s that were explained simply by neutrino oscillation, or the ability of neutrinos to transform from one type into another and back again. This research showed conclusively there is more to the story.
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- Study tests oral insulin to prevent type 1 diabetes
01-31-2007 · EurekAlert!
Researchers have begun a clinical study of oral insulin to prevent or delay type 1 diabetes in at-risk people, the National Institutes of Health announced today. Type 1 Diabetes TrialNet, an NIH-funded network of researchers dedicated to the understanding, prevention, and early treatment of type 1 diabetes, is conducting the study in more than 100 medical centers across the United States, Canada, Europe and Australia.
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- Joslin study indicates insulin receptors play a critical role in promoting islet growth
04-02-2007 · EurekAlert!
A new Joslin-led study has identified the insulin receptor as an important protein that promotes islet cell growth in mice whose bodies are unable to use insulin properly, or are insulin resistant, a precursor to type 2 diabetes.
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- In mice, drug protects against diabetes and atherosclerosis
06-06-2007 · EurekAlert!
Blocking a single protein with an experimental drug prevented and treated both type 2 diabetes and atherosclerosis in laboratory mice that had been fed unhealthy diets and were genetically predisposed to these common killers, according to a team led by Gцkhan Hotamisligil at HSPH.
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08-29-2007 · EurekAlert!
New findings from studies in mice suggest that defects in the brain's ability to respond to glucose play a role in the development of non-insulin dependent (type 2) diabetes, and that a high-fat diet may contribute to impairing brain cells' ability to regulate glucose throughout the body.
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