science top stories popular news  

Daily non-political popular news in brief.

Jefferson scientists find aging gene also protects against prostate cancer development

11-27-2006 · EurekAlert!

Cancer researchers have found that a gene that is involved in regulating aging also blocks prostate cancer cell growth. They have shown that the enzyme SIRT1 can block the growth of treatment-resistant prostate cancer cells that overexpress a mutation for the androgen receptor. The scientists hope the newly found connection will aid in better understanding the development of prostate cancer and lead to new drugs against the disease.

Read more »

Keywords: jefferson, scientists, aging, gene, protects, prostate, cancer, development, scientist, protect

« Previous | Next »

Similar news on "Jefferson scientists find aging gene also protects against prostate cancer development":

  1. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
    10-11-2007 · EurekAlert!
    A tumor-blocking protein previously implicated in prostate and breast cancer development may also be behind the most aggressive type of pancreatic cancer. Researchers have discovered that the protein pp32 -- which normally applies the brakes on a cancer-causing gene -- is missing in an aggressive form of pancreatic cancer. Though the work is preliminary, the scientists say, the absent protein could eventually become a marker for the disease and a potential drug target.
    Similar news · Read more »
  2. Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
    11-01-2006 · EurekAlert!
    Cell biologists have provided further evidence that a gene thought to play a role in suppressing tumors actually protects against the development of pre-cancerous cell growth as well. The researchers say that the gene, caveolin-1, which they found in two major types of breast cells, could be a potential target for future drugs aimed at preventing breast cancer. The work also suggests a potentially important role of the tumor "microenvironment" in the cancerous process.
    Similar news · Read more »
  3. Jefferson scientists find guardian gene's choices crucial to stopping cancer process
    01-05-2007 · EurekAlert!
    Scientists at the Kimmel Cancer Center at Thomas JeffersonUniversity have uncovered a novel pathway by which the anti-cancer gene p53 springs into action, protecting a damaged cell from becoming cancer. The gene can either halt the cell's growth or send it spiraling toward certain death. How this choice is made, the researchers say, could have implications for future strategies in chemotherapy drug development.
    Similar news · Read more »
  4. Jefferson scientists uncover role of cancer stem cell marker: controlling gene expression
    01-17-2008 · EurekAlert!
    Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary advance in the understanding of the function of a gene previously shown to be part of an 11-gene "signature" that can predict which tumors will be aggressive and likely to spread. The gene, USP22, encodes an enzyme that appears to be crucial for controlling large scale changes in gene expression, one of the hallmarks of cancer cells.
    Similar news · Read more »
  5. Colon cancer a disease of hormone deficiency, Jefferson team finds
    08-01-2007 · EurekAlert!
    Researchers have found new evidence suggesting that colon cancer is a disease of missing hormones that could potentially be treated by hormone replacement therapy.Early in colon cancer development, two intestinal cell growth-controlling hormones are "lost," disrupting the activity of the hormones' receptor, GCC. Using two mouse models of colon cancer development in people, the scientists showed that GCC signaling blocks tumors from forming, meaning that colon cancer could be a disease of hormone insufficiency.
    Similar news · Read more »
  6. Jefferson scientists find rabies-based vaccine could be effective against HIV
    04-03-2007 · EurekAlert!
    Rabies, a relentless, ancient scourge, may hold a key to defeating another implacable foe: HIV. Scientists have used a drastically weakened rabies virus to ferry HIV-related proteins into animals, in essence, vaccinating them against an AIDS-like disease. Early evidence indicates that the vaccine -- which doesn’t protect against infection -- prevents development of disease. Two years after the initial vaccination, four non-human primates were protected from disease, even after being "challenged" with a dangerous animal-human virus.
    Similar news · Read more »
  7. Two studies: Speeding development of novel tracer for prostate cancer
    01-02-2007 · EurekAlert!
    The collaborative work being performed by professionals across medical disciplines in the promising area of molecular imaging -- from research scientists to nuclear medicine physicians, urologists, radiochemists and even veterinarians -- provides encouraging news in fighting prostate cancer. This type of progressive -- or translational -- research can be seen in two papers published in the January issue of the Journal of Nuclear Medicine.
    Similar news · Read more »
  8. New clues to breast cancer development in high-risk women
    09-11-2007 · EurekAlert!
    Physicians who treat women with the breast cancer susceptibility gene BRCA1 often remove their patients' ovaries to eliminate the source of estrogen they believe fuels cancer growth. Yet they also know that anti-estrogen therapies don't work to treat breast or ovarian cancer that might develop. That paradox has led scientists to question exactly how, or if, estrogen is involved in cancer development and whether removal of ovaries makes sense.
    Similar news · Read more »
  9. Einstein researchers use novel approach to uncover genetic components of aging
    08-24-2007 · EurekAlert!
    People who live to 100 or more are known to have just as many -- and sometimes even more -- harmful gene variants compared with younger people. Now, scientists at the Albert Einstein College of Medicine of Yeshiva University have discovered the secret behind this paradox: favorable "longevity" genes that protect very old people from the bad genes' harmful effects. The novel method used by the researchers could lead to new drugs to protect against age-related diseases.
    Similar news · Read more »
  10. Blocking cancer-causing gene improves radiation effectiveness, Jefferson researchers find
    11-08-2006 · EurekAlert!
    Inhibiting a particular cancer-causing gene can enhance the cell-killing effects of radiation, a team of radiation oncologists and cancer biologists has found. Using a combination of zebrafish and antisense technology, they've shown that the drug flavopiridol works by blocking the activity of a gene, cyclin D1, which is overexpressed in about half of all breast cancers. Similar techniques in the future, the scientists say, may enable researchers to better gauge the effects of drugs.
    Similar news · Read more »