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Signaling for cartilage

Skeletal progenitor cells differentiate into cartilage cells when one master gene actually suppresses the action of another. Skeletons are made of bone and cartilage cells that are differentiated from the same multipotent stem cell, which gives rise to bone, cartilage, fat and fibroblasts.

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Keywords: signaling, cartilage

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1. Gene therapy research switches off joint inflammation; switches on genetic process of joint repair
   10-18-2006 · EurekAlert!
   Scientists at Case Western Reserve University School of Medicine and Albany Medical College, together with Rainforest Nutritionals, Inc. have demonstrated today at the 14th International Conference of the Inflammation Research Association (IRA) that a blend of natural botanical products called Reparage have turned on the master repair gene, IGF-1, which is responsible for growing human cartilage and restores joint function while blocking joint destruction associated with inflammation.
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2. Shark cartilage shows no benefit as a therapeutic agent for lung cancer
   06-02-2007 · EurekAlert!
   In the first scientific study of its kind, shark cartilage extract, AE-941 or Neovastat, has shown no benefit as a therapeutic agent when combined with chemotherapy and radiation for patients with advanced non-small cell lung cancer, according to researchers at the University of Texas M. D. Anderson Cancer Center.
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3. Gene therapy inhibits epilepsy in animals
   11-08-2006 · EurekAlert!
   For the first time, researchers have inhibited the development of epilepsy after a brain insult in animals. By using gene therapy to modify signaling pathways in the brain, neurology researchers found that they could significantly reduce the development of epileptic seizures in rats. "We have shown that there is a window to intervene after a brain insult to reduce the risk that epilepsy will develop," said one of the lead researchers.
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4. News tips from the Journal of Neuroscience
   03-06-2007 · EurekAlert!
   The following articles are featured in the upcoming issue of the Journal of Neuroscience: A Siphon Hypothesis Goes Down the Tube; Presynaptic TrkB Signaling; A CRF1 Antagonist as Treatment for Alcohol Dependence in Rats; and Paraquat-Induced Parkinsonism in the Fly.
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5. Banding together: RAS signaling of circadian output
   06-14-2007 · EurekAlert!
   In the June 15 issue of G&D, Drs. Jay Dunlap and Jennifer Loros, with colleagues at Dartmouth Medical School, have finally cloned the band gene, and have found that it is an allele of ras-1. This finding posits RAS signaling as a key mediator of circadian output.
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6. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
   08-23-2007 · EurekAlert!
   Angiogenesis inhibitors that block a tumor's development of an independent blood supply have been touted as effective cancer fighters that result in fewer side effects than traditional chemotherapy. However, a new study by researchers at UCLA's Jonsson Cancer Center showed that one method of blocking blood supply development could result in serious and potentially deadly side effects.
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7. Brain circuits that control hunger identified
   10-29-2007 · EurekAlert!
   Researchers at UCLA have determined the brain circuits involved in hunger that are influenced by a hormone called leptin. In previous clinical trials, supplementation of leptin, the signaling molecule produced by fat cells, produced moderate weight loss in some obese patients, purportedly by inhibiting hunger and promoting feelings of being full. Thus, this new work suggests possible new targets for treating obesity.
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8. USC researchers identify mechanism that controls activation of stem cells during hair regeneration
   01-16-2008 · EurekAlert!
   Researchers at the University of Southern California have identified a novel cyclic signaling in the dermis that coordinates stem cell activity and regulates regeneration in large populations of hairs in animal models.
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9. Mayo researchers note that stronger leg muscles can protect against knee osteoarthritis
   11-14-2006 · EurekAlert!
   Stronger quadriceps muscles in the legs can help protect against cartilage loss behind the kneecap, according to Mayo Clinic researchers presenting preliminary study data at the American College of Rheumatology Annual Meeting on Nov. 15.
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10. Using coxibs and NSAIDs to treat osteoarthritis
    08-13-2007 · EurekAlert!
    In an editorial, to be published in the international journal Osteoarthritis and Cartilage, published by Elsevier, a panel of arthritis research experts has recommended that coxibs and nonsteroidal anti-inflammatory drugs must remain a significant part of the tool kit used in treating osteoarthritis.
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