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'Cancer prognosis gene' found to control the fate of breast cells
11-30-2006 · EurekAlert!Scientists have discovered an unsuspected role for a gene known to be one of the best predictors of human breast cancer outcome.
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Keywords: cancer, prognosis, gene, control, fate, breast, cells, prognosi, cell
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04-19-2007 · EurekAlert!
The cancerous cells of some individuals with breast cancer lack expression of two cell surface proteins, the estrogen and progesterone receptors, and do not express increased amounts of HER2. Individuals with such breast cancer (known as triple-negative breast cancer) do not respond to treatment with commonly used chemotherapeutic drugs and their prognosis is relatively poor. But a new study has indicated why triple-negative breast cancer cell lines are sensitive to exposure to the chemotherapeutic cisplatin.
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- Jefferson scientists show gene reverts cancer genes to normal, predicts breast cancer prognosis
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Scientists have shown that the activity of a gene that commandeers other cancer-causing genes, returning them to normal, can predict the prognosis of an individual with breast cancer. They looked at cancer cells from more than 2,000 breast cancer patients and found that this commandeering or "organizing" ability is increasingly lost in cancer cells and associated with the progression of disease. The more the gene is expressed in breast cancer, the better the patient did.
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11-01-2006 · EurekAlert!
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A Dana-Farber Cancer Institute study challenges the hypothesis that "cancer stem cells" -- a small number of self-renewing cells within a tumor -- are responsible for breast cancer progression and recurrence, and that wiping out these cells alone could cure the disease.
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08-27-2007 · EurekAlert!
Sheets of highly organized epithelial cells line all the cavities and freesurfaces of the body, forming barriers that control the movement of liquidsand cells in the body organs. Now, the researchers at the University of Helsinki, Finland, have found that the organized structure of normal breast epithelial cells may also serve as a barrier against cancer.
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A new study may explain why women with a mutation in the BRCA1 gene face up to an 85 percent lifetime risk of breast cancer. Researchers from the University of Michigan Comprehensive Cancer Center found that BRCA1 plays a role in regulating breast stem cells, the small number of cells that might develop into cancers.
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07-31-2007 · EurekAlert!
Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death. The work suggests that drugs designed to disable the enzyme, known as TOPK, could have anticancer benefits. The study appears in the July issue of the journal Gastroenterology.
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