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Protein protects against nerve degeneration
11-30-2006 · EurekAlert!A protein called NMNAT protects against nerve cell degeneration in fruit flies and mice. The finding begs the question if a drug might be developed that could stimulate extra protein production and thus neuronal protection -- both in injured cells and in those degenerating because of disease.
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Keywords: protein, protects, nerve, degeneration, protect
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- Deactivating protein may protect nerve fibers in MS
04-23-2007 · EurekAlert!
Oregon Health & Science University neuroscientists are eyeing a protein as a potential therapeutic target for multiple sclerosis because de-activating it protects nerve fibers from damage. OHSU researchers have shown that genetically inactivating a protein called cyclophilin D can protect nerve fibers in a mouse model of multiple sclerosis. Cyclophin D is a key regulator of molecular processes in the nerve cell's powerhouse, the mitochondrion, and can participate in nerve fiber death.
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- VEGF-B helps nerve cells cheat death without unwanted side effects
02-07-2008 · EurekAlert!
The prototypical member of the VEGF family of proteins, VEGF, protects cells in the nervous system from death and degeneration. However, its clinical utility in this regard is limited, because it also induces blood vessel growth, a process known as angiogenesis. However, a new study has revealed that another VEGF family member, VEGF-B, does not have such limitations as it acts as a potent inhibitor of murine retinal cell death while exerting minimal angiogenic effects.
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- Carbon monoxide protects mice from multiple sclerosis
01-25-2007 · EurekAlert!
Multiple sclerosis (MS) is a chronic inflammatory disorder that causes degeneration of the nerves in the brain and spinal cord, leading to various symptoms including muscle weakness and pain. Using a mouse model of MS (known as EAE), researchers have now shown that increased expression of a protein known as HO-1, as well as administration of carbon monoxide, protects mice from disease.
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- Researchers find 'zip code' spurs cargo transport in neurons
10-24-2006 · EurekAlert!
Getting molecular cargo from the cell body to the synapse of nerve cells is crucial for learning and memory, even for survival of the cell itself. New research conducted at Brown University and the Marine Biological Laboratory in Woods Hole, Mass., shows that a single peptide can load and direct this biological material. This peptide "ZIP Code" comes from amyloid precursor protein, the principal player in the development of Alzheimer's disease.
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- Protein in human hair shows promise for regenerating nerves
01-10-2008 · EurekAlert!
A protein found in human hair shows promise for promoting the regeneration of nerve tissue and could lead to a new treatment option when nerves are cut or crushed from trauma.
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- Intravenous gene therapy protects normal tissue of mice during whole-body radiation
11-07-2006 · EurekAlert!
Gene therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb. In the University of Pittsburgh study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation.
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- Tips from the Journals of the American Society for Microbiology
03-19-2007 · EurekAlert!
New Study Suggests Antiviral Protein May Inhibit Ebola and Marburg Virus; Probiotic Treatment Reduces Salmonella Infection in Pigs and Protein Found in Chickens May Help Protect Against Food-Borne Pathogens are story tips from the Journals of the American Society for Microbiology.
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- Antibodies protect mice from developing respiratory tularemia
06-27-2007 · EurekAlert!
A research team led by Dennis W. Metzger, Ph.D., at the Albany Medical College in New York has now shown that treating laboratory mice with a serum containing tularemia-specific antibodies protects the mice against F. tularensis, not only if given before exposure to lethal doses of inhalational F. tularensis but also up to 48 hours after exposure. These findings suggest a possible alternative treatment approach to traditional antibiotics.
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- Intravenous gene therapy protects normal tissue of mice during whole-body radiation
10-28-2007 · EurekAlert!
Gene therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb. In the University of Pittsburgh study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome gene therapy on the bone marrow during whole-body irradiation.
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- Parkinson's protein protects neurons from stress induced cell death
05-21-2007 · EurekAlert!
Parkinson's disease, also known as shaking palsy, is one of the most frequent diseases of the nervous system. In a collaborative effort the groups of Dr. Konstanze Winklhofer (Ludwig-Maximilians-University Munich) and Dr. Daniel Krappmann (GSF -- Research Center for Environment and Health, Neuherberg) have now been able to reveal a novel function for the Parkin protein.
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