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Parkinson's approach with stem cells a promising first step
12-01-2006 · EurekAlert!Brain cells derived from human embryonic stem cells improved the condition of rats with Parkinson's-like symptoms dramatically, but the treatment caused a significant problem -- the appearance of brain tumors -- that scientists are now working to solve. The study is featured on the cover of the November issue of Nature Medicine.
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- Mouse stem cell line advance suggests potential for IVF-incompetent eggs
02-19-2007 · EurekAlert!
Researchers have found that mouse oocytes that fail to become fertilized during in vitro fertilization are nevertheless often capable of succeeding as "cytoplasmic donors" during a subsequent cloning step using so-called nuclear transfer. Although the implications for human eggs are not yet clear, the findings are of interest because of the ethical and practical concerns surrounding the need for fresh human oocytes for similar nuclear-transfer procedures using human cells.
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- Muscle stem cells effectively treat urinary incontinence long term
05-21-2007 · EurekAlert!
Women with stress urinary incontinence (SUI) treated using muscle-derived stem cell injections to strengthen their sphincter muscles experience long-term improvements in their condition, according to a study led by researchers at the University of Pittsburgh School of Medicine and Sunnybrook Health Sciences Center in Toronto. The study, which followed patients for more than one year, suggests that the approach is safe, improves patients' quality of life and may be an effective treatment for SUI.
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- Advance helps explain stem cell behavior
11-20-2006 · EurekAlert!
Biochemists at Oregon State University have developed a new method to identify the "DNA-binding transcription factors" that help steer stem cells into forming the wide variety of cells that ultimately make up all the organs and parts of a living vertebrate animal. The research is an important step towards understanding stem cell behavior and how cellular development is controlled.
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- Neuroscientist comments on stem cell study's success in helping primates with Parkinson's
07-10-2007 · EurekAlert!
A University of South Florida neuroscientist reports that the cutting-edge research study of human stem cells in primates with Parkinson's disease is compelling on several fronts -- particularly how the transplanted cells did their job of easing disease symptoms.
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- Scientists produce neurons from human skin
02-22-2007 · EurekAlert!
Scientists from Université Laval's Faculty of Medicine have succeeded in producing neurons in vitro using stem cells extracted from adult human skin. This is the first time such an advanced state of nerve cell differentiation has been achieved from human skin, according to lead researcher Professor François Berthod. This breakthrough could eventually lead to revolutionary advances in the treatment of neurodegenerative illnesses such as Parkinson's disease.
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- Chemical cues turn embryonic stem cells into cerebellar neurons
03-14-2007 · EurekAlert!
Rockefeller University scientists show that embryonic stem cells implanted in the brain appear to develop into fully differentiated granule neurons, the most plentiful neuron in the cerebellum. The findings are a step toward understanding how embryonic stem cells could be regulated in vivo and ultimately used for cell replacement therapy, especially after childhood tumors, in the central nervous system.
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- Replacing the cells lost in Parkinson disease
12-03-2007 · EurekAlert!
Parkinson disease is caused by the progressive degeneration of dopamine brain cells. Replacing these cells is considered a promising therapeutic strategy. Although DA cell-replacement therapy by transplantation of human fetal mesencephalic tissue has shown promise, limited tissue availability means other sources of these cells are needed. A recent study has described one new source for DA cells that provided marked benefit when transplanted into mice with a PD-like disease.
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- JCI table of contents: Dec. 3, 2007
12-03-2007 · EurekAlert!
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published Dec. 3, 2007, in the JCI, including: Promising approach to a more effective sunscreen; Modifying an anticancer drug makes it more specific; Giving asthma T(he)SL(i)P by blocking OX40; Treating type 1 diabetes by eliminating B cells; On the origin of the fat cell; You snooze, you don’t lose: Cellular repercussions of sleep deprivation; and others.
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- Milestone in the regeneration of brain cells
08-20-2007 · EurekAlert!
Neuherberg, 20 Aug. The research group of Prof. Dr. Magdalena Götz at the Institute of Stem Cell Research of the GSF -- National Research Centre for Environment and Health, and the Ludwig Maximilians University, Munich, has achieved an additional step for the potential replacement of damaged brain cells after injury or disease: functional nerve cells can be generated from astroglia, a type of supportive cells in the brain by means of special regulator proteins.
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- UCLA scientists produce functioning neurons from human embryonic stem cells
08-07-2007 · EurekAlert!
Scientists with the Institute of Stem Cell Biology and Medicine at UCLA were able to produce from human embryonic stem cells a highly pure, large quantity of functioning neurons that will allow them to create models of and study diseases such as Alzheimer's, Parkinson's, prefrontal dementia and schizophrenia.
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