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Cancer Link: Gene regulates progesterone effect on breast cells

12-02-2006 · Science News Online

The BRCA1 protein regulates the effect of pro-growth progesterone, which could explain why having a mutated

Keywords: cancer, link, gene, regulates, progesterone, effect, breast, cells, regulate, cell

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Fetal cell 'transplant' could be a hidden link between childbirth and reduced risk of breast cancer
10-02-2007 · EurekAlert!
Some benefits of motherhood are intangible, but one has been validated through biostatistical research: women who bear children have a reduced risk of developing breast cancer. In Seattle, researchers at the University of Washington and Fred Hutchinson Cancer Research Center believe they have identified a source of this protective effect: fetal cells "transplanted" to the mother before birth.
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Why cisplatin kills breast cancer cells when other drugs fail
04-19-2007 · EurekAlert!
The cancerous cells of some individuals with breast cancer lack expression of two cell surface proteins, the estrogen and progesterone receptors, and do not express increased amounts of HER2. Individuals with such breast cancer (known as triple-negative breast cancer) do not respond to treatment with commonly used chemotherapeutic drugs and their prognosis is relatively poor. But a new study has indicated why triple-negative breast cancer cell lines are sensitive to exposure to the chemotherapeutic cisplatin.
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Researchers first to map gene that regulates adult stem cell growth
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A new discovery in stem cell research may mean big things for cancer patients in the future. After being the first to genetically map and identify a gene that regulates adult stem cells, the researchers investigated the gene's protein product, Latexin, which can be used to ramp up the body's stem cell count. The team's findings are being published in Nature Genetics.
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Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
11-01-2006 · EurekAlert!
Cell biologists have provided further evidence that a gene thought to play a role in suppressing tumors actually protects against the development of pre-cancerous cell growth as well. The researchers say that the gene, caveolin-1, which they found in two major types of breast cells, could be a potential target for future drugs aimed at preventing breast cancer. The work also suggests a potentially important role of the tumor "microenvironment" in the cancerous process.
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Developmental biologists at Rice University have found that a gene called LMO4, which is known to play roles in both cell reproduction and in breast cancer, also plays a role in neurological development. By both knocking out and overexpressing the gene in zebrafish, the scientists determined that LMO4 independently regulates two other genes that are involved with the development of the forebrain and eyes. The results are slated to appear in the journal Developmental Biology.
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Linchpin gene may be useful target for new breast cancer therapies
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University of Iowa researchers have discovered a gene that plays a linchpin role in the ability of breast cancer cells to respond to estrogen. The finding may lead to improved therapies for hormone-responsive breast cancers, and may explain differences in the effectiveness of current treatments.
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BRCA1 mutation linked to breast cancer stem cells
01-31-2008 · EurekAlert!
A new study may explain why women with a mutation in the BRCA1 gene face up to an 85 percent lifetime risk of breast cancer. Researchers from the University of Michigan Comprehensive Cancer Center found that BRCA1 plays a role in regulating breast stem cells, the small number of cells that might develop into cancers.
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Fetal heart-cell enzyme important in onset of heart failure
02-18-2007 · EurekAlert!
In almost all forms of heart failure, the heart begins to express genes that are normally only expressed in the fetal heart. Researchers have known for years that this fetal-gene reactivation happens, yet not what regulates it. Now, investigators at the Penn have discovered that an enzyme important in fetal heart-cell development regulates the enlargement of heart cells, known as cardiac hypertrophy, which is a precursor to many forms of congestive heart failure.
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A Dana-Farber Cancer Institute study challenges the hypothesis that "cancer stem cells" -- a small number of self-renewing cells within a tumor -- are responsible for breast cancer progression and recurrence, and that wiping out these cells alone could cure the disease.
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