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Early HIV treatment fails to restore memory T cells
12-04-2006 · EurekAlert!Most of the body's memory T cells vanish within weeks after a person is infected with the HIV virus. In a study from the Aaron Diamond AIDS Research Center and the Bernard-Nocht Institute appearing in the international open-access journal PLoS Medicine, researchers report that these memory T cells, mostly found in the digestive tract, tend not to return to normal even after years of treatment for HIV.
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Keywords: hiv, treatment, fails, restore, memory, cells, fail, cell
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- Why cisplatin kills breast cancer cells when other drugs fail
04-19-2007 · EurekAlert!
The cancerous cells of some individuals with breast cancer lack expression of two cell surface proteins, the estrogen and progesterone receptors, and do not express increased amounts of HER2. Individuals with such breast cancer (known as triple-negative breast cancer) do not respond to treatment with commonly used chemotherapeutic drugs and their prognosis is relatively poor. But a new study has indicated why triple-negative breast cancer cell lines are sensitive to exposure to the chemotherapeutic cisplatin.
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- Antidepressants stimulate new nerve cells in adult monkeys, may have implications for humans
05-04-2007 · EurekAlert!
In adult monkeys, an antidepressant treatment has induced new nerve cell growth in the hippocampus, a brain area responsible for learning and memory. A similar process may occur in humans, the research suggests, and may help explain the effectiveness of antidepressant treatments.
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- HIV is a 'double hit' to the brain
08-15-2007 · EurekAlert!
New evidence reported in the August issue of Cell Stem Cell, a publication of Cell Press, offers a novel perspective on how the HIV/AIDS virus leads to learning and memory deficits, a condition known as HIV-associated dementia. A protein found on the surface of the virus not only kills some mature brain cells, as earlier studies had shown, but it also prevents the birth of new brain cells by crippling "adult neural progenitors," the new study finds.
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- International HIV/AIDS trial finds risks increase on episodic antiretroviral therapy
11-29-2006 · EurekAlert!
Results from one of the largest HIV/AIDS treatment trials ever conducted show that a specific strategy of interrupting antiretroviral therapy more than doubles the risk of AIDS or death from any cause. In the study, the investigators used two predetermined levels of CD4+ T cells, the primary immune cell targeted by HIV, to guide them in respectively suspending or restarting the study participants on antiretroviral therapy.
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- New hope for children when leukemia treatment fails
10-16-2006 · EurekAlert!
Clinicians at St. Jude Children's Research Hospital have successfully demonstrated an improved technique for blood stem cell transplantations in children that shows promise for those most likely to fail standard treatment for leukemia.
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- A new method of adult stem cell growth efficacious in treatment of disorders of the cornea
07-19-2007 · EurekAlert!
A new method of adult stem cell growth, designed in the Area of Cellular Therapy of the University Clinic (University of Navarra), has demonstrated its efficacy for its capacity to grow cornea stem cells.
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- Stem cells show promise for treating Huntington's disease
09-25-2007 · EurekAlert!
Paying close attention to how a canary learns a new song has helped scientists open a new avenue of research against Huntington's disease -- a fatal disorder for which there is currently no cure or even a treatment to slow the disease. Scientists used gene therapy to guide the development of endogenous stem cells in the brains of mice affected by a form of Huntington’s, generating new medium spiny neurons -- the cell lost in Huntington's disease.
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- Researchers find 'zip code' spurs cargo transport in neurons
10-24-2006 · EurekAlert!
Getting molecular cargo from the cell body to the synapse of nerve cells is crucial for learning and memory, even for survival of the cell itself. New research conducted at Brown University and the Marine Biological Laboratory in Woods Hole, Mass., shows that a single peptide can load and direct this biological material. This peptide "ZIP Code" comes from amyloid precursor protein, the principal player in the development of Alzheimer's disease.
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- Neural stem cells lend the brain a surprising capacity for self-repair
12-14-2006 · EurekAlert!
The brain contains stem cells with a surprising capacity for repair, researchers report in the Dec. 15 issue of the journal Cell, published by Cell Press. The novel insight into the brain's natural ability to heal might ultimately have clinical implications for the treatment of brain damage, according to the researchers.
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- When smell cells fail they call in stem cell reserves
04-29-2007 · EurekAlert!
Hopkins researchers have identified a backup supply of stem cells that can repair the most severe damage to the nerves responsible for our sense of smell. These reservists normally lie around and do nothing, but when neighboring cells die, the scientists say, the stem cells jump into action. A report on the discovery will appear online next week in Nature Neuroscience.
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