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Penn researchers discover initial steps in the development of taste
12-05-2006 · EurekAlert!Researchers at the University of Pennsylvania School of Medicine are closer to understanding how the sense of taste develops. They have pinpointed a molecular pathway that regulates the development of taste buds. Using genetically engineered mice, they discovered that a signaling pathway activated by small proteins called Wnts is required for initiating taste-bud formation. They have also determined that Wnt proteins are required for hooking up the wiring of taste signals to the brain.
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- Researchers at IRB Barcelona discover one of the mechanisms that prevents the spread of colon cancer
09-30-2007 · EurekAlert!
The first step in the development of colon cancer is the formation of benign tumors, called adenomas, in the intestine. Over time, these tumors may progress to produce colon cancer if they undergo a series of mutations and genetic alterations. Researchers at IRB Barcelona under the direction of Eduard Batlle, head of IRB Barcelona's Oncology Program, have discovered a new mechanism by which the benign tumor cells receive instructions to grow in confined compartments, and no to invade other areas of the tissue.
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- Researchers move 2 steps closer to understanding genetic underpinnings of autism
01-10-2008 · EurekAlert!
Today's issue of the American Journal of Human Genetics, describes what might be a corner piece of the autism puzzle -- the identification and subsequent validation of a gene linked to the development of autism by three separate groups of scientists. An accompanying commentary by Dr. Dietrich Stephan, Director of the Neurogenomics Division at the Translational Genomics Research Institute, further explains the findings.
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- Bank on a Cure researchers identify pathways mediating myeloma treatment side effects
12-11-2006 · EurekAlert!
Thalidomide is a widely prescribed treatment for multiple myeloma. However, an estimated 15 to 30 percent of patients suffer venous thromboembolisms (VTEs), blood clots, as a major complication. The Bank On A Cure DNA-bank researchers have identified four gene clusters associated with the VTEs. Identifying the associated single nucleotide polymorphisms (SNPs) for use as markers, may lead to the development of screenings and tailored interventions to prevent these side effects, as a major step toward personalized medicine.
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- Support for chromosomal theory of cancer found in cancers' development of drug resistance
06-27-2007 · EurekAlert!
Most cancer researchers are convinced that cancer results from a handful of genetic mutations that kick a cell into uncontrolled growth. UC Berkeley genetics researcher Peter Duesberg disagrees, and finds support for his "chromosomal" theory of cancer in the development of drug resistance by many cancers. While his theory implies their is no magic bullet against cancer, it does provide ways to detect cancer at an early stage.
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- Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease
12-13-2007 · EurekAlert!
Researchers discover a new regulatory element in a region of the cystic fibrosis gene that can control the gene's expression in the gastrointestinal tract, offering new insight into it's role in the development of digestive diseases.
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- Penn researchers discover new mechanism for viral replication
08-16-2007 · EurekAlert!
Researchers have identified a new strategy that Kaposi's Sarcoma Associated Herpesvirus uses to dupe infected cells into replicating its viral genome. This is the first study to directly show that a section of viral DNA can independently draw upon proteins within a host cell to promote its own replication.
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- New simulator is next step on the road to developing quantum computers
11-26-2006 · EurekAlert!
Scientists have proven theoretically a novel way to build a simulator that can recreate the way atoms and particles behave in a quantum system, says research published today. The proposed simulator is unique because it could let researchers control how individual particles move and interact with each other. This ability to control individual parts of a quantum system is key to the development of powerful quantum computers in the future.
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- NIH scientists discover novel cause of iron overload in thalassemia disorders
08-30-2007 · EurekAlert!
Researchers at NIH have discovered a novel cause of iron overload in patients with thalassemia. According to the study, thalassemia patients overproduce a protein called GDF15, which suppresses the production of a liver protein, hepcidin, which in turn leads to an increase in the uptake of dietary iron in the gut. This finding has implications for iron metabolism in other diseases and may contribute to the future development of therapies for thalassemia.
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- First autism prevention study launched by University of Washington
01-02-2008 · EurekAlert!
Autism researchers at the University of Washington will take the initial step in attempting to prevention the developmental disorder when they launch an $11.3 million study this week.
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- Penn researchers shine the light of venus to learn how the herpes virus invades cells
12-13-2007 · EurekAlert!
University of Pennsylvania researchers have uncovered an important step in how herpes simplex virus, HSV-1, uses cooperating proteins found on its outer coat to gain entry into healthy cells and infect them. Further, the study’s authors say, they have demonstrated the effectiveness of monitoring these protein interactions using biomolecular complementation.
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