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Protein-based tumor biomarker predicts breast-cancer survival
12-05-2006 · EurekAlert!The first and largest clinical trial of its kind confirms that a protein called p27 may be a valuable tool for predicting survival after a diagnosis of breast cancer.
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Keywords: protein-based, tumor, biomarker, predicts, breast-cancer, survival, protein, based, predict, breast, cancer
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- New biomarker predicts effectiveness of breast cancer drugs
12-07-2006 · EurekAlert!
University of Cincinnati researchers have identified a new way to predict when anti-estrogen drug therapies are inappropriate for patients with hormone-dependent breast cancer.Scientists say these findings could help physicians more accurately predict which tumors will respond to anti-estrogen therapy and improve long-term survival for breast cancer patients.
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- Cell response to stress signals predicts tumors in women with common pre-breast cancer
11-12-2007 · EurekAlert!
A specific biological response to cellular stress may predict the likelihood of future tumor formation of the most common, noninvasive form of pre-malignant breast cancer -- ductal carcinoma in situ, or DCIS.
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- Researchers find two biomarkers with potential to predict breast cancer spread
12-15-2006 · EurekAlert!
Expression of two different proteins taken from primary tumor biopsies is highly associated with spread of breast cancer to nearby lymph nodes, according to researchers who say this protein profile could help identify at an early stage those patients whose disease is likely to metastasize.
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- Sidestepping cancer's chaperone
10-18-2007 · EurekAlert!
Researchers at the University of Massachusetts Medical School, have defined a method to target and kill cancer's 'chaperone' -- a protein that promotes tumor cell stability and survival -- without damaging healthy cells nearby.
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- Genomic 'firestorms' underlie aggressive breast cancer progression
11-30-2006 · EurekAlert!
The first high-resolution analysis of genomic alterations in breast tumors is reported in the scientific journal Genome Research. In this analysis, scientists from Cold Spring Harbor Laboratory, in collaboration with researchers from Scandinavia, identified three distinct patterns of genomic variation that underlie breast tumor formation, one of which -- "firestorms" -- may be predictive of aggressive disease progression and short survival.
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- UT Health Science Center researchers decoding saliva to detect breast cancer
01-10-2008 · EurekAlert!
Researchers at The University of Texas Health Science Center at Houston can identify and quantify specific protein markers in human saliva to provide an early, non-invasive diagnosis of breast cancer, according to a study appearing today in the journal Cancer Investigation. The study is being applied to "lab-on-a-chip" technology that may bring this type of diagnostic test -- capable of detecting the presence of cancer before a tumor forms -- into everyday use.
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- Does neural cell adhesion molecule-180 predict survival in colorectal cancer?
11-02-2007 · EurekAlert!
As cancer is one of the most fatal diseases worldwide, tumor markers and prognostic criterions are of great interest to researchers. Tumor suppressors and cell adhesion molecules play crucial roles in tumor pathophysiology, acting as potential targets for treatment modalities. NCAM-180 is a structural molecule that mediates cell-cell adhesion, resulting in tissue stabilization. It has been proposed as a tumor suppressor in colon carcinoma. A research group in Turkey has investigated the prognostic value of NCAM-180 in colorectal cancer.
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- Other highlights from the June 6 JNCI
06-05-2007 · EurekAlert!
Also in the June 6 JNCI is an association between aspirin use and decreased risk of cancer, a protein that suppresses tumor growth and cell migration, the incidence of a rare cancer in Denmark, and a protein that is not associated with inflammation, but not breast cancer.
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- Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
10-11-2007 · EurekAlert!
A tumor-blocking protein previously implicated in prostate and breast cancer development may also be behind the most aggressive type of pancreatic cancer. Researchers have discovered that the protein pp32 -- which normally applies the brakes on a cancer-causing gene -- is missing in an aggressive form of pancreatic cancer. Though the work is preliminary, the scientists say, the absent protein could eventually become a marker for the disease and a potential drug target.
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- Biomarkers predict risk for invasive breast cancer years before the tumor develops
11-12-2007 · EurekAlert!
A team of scientists from the University of California San Francisco has identified distinct molecular markers that predict whether or not a woman is likely to develop subsequent invasive cancer after initial diagnosis with a noninvasive form of early breast cancer. The research, published by Cell Press in the November issue of Cancer Cell, provides critical information that can be used to determine whether a woman should receive more or less aggressive therapy.
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